老年慢性心力衰竭稳定期病人心肺功能、运动耐力特征及NT-proBNP和TNT分析

doi:10.3969/j.issn.1003-9198.2023.11.014

Abstract

Abstract: Objective To observe and analyze the characteristics of cardiopulmonary function and exercise endurance, the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and Troponin T (TNT) in the elderly patients with stable chronic heart failure (CHF). Methods A total of 102 patients with stable CHF in our hospital from October 2020 to October 2022 were collected, and 50 healthy individuals who received physical examination during the same period were selected as control group. The cardiac function indexes, lung function indexes and serum levels of NT-proBNP, TNT and the 6-min walk distance (6MWD) were observed and compared among the groups. Results A total of 61 cases (59.80%) in the CHF group had lung function impairment, and the incidence rate of lung function impairment was higher in NYHA grade Ⅲ group than that in grade Ⅰ/Ⅱ group (69.23% vs 53.97%,P<0.05). The levels of left ventricular ejection fraction(LVEF), forced vital capacity(FVC), forced expiratory volume in one second(FEV1), FEV1/FVC, total lung capacity(TLC), diffusion capacity for carbon monoxide of the lung(DLCO) and 6MWD in CHF group were significantly lower than those in control group, and were significantly lower in NYHA grade Ⅲ group than those in grade Ⅰ/Ⅱ group. The levels of left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left atrial diameter (LAD) and blood NT-proBNP and TNT levels in CHF group were significantly higher than those in control group, and were significantly higher in NYHA grade Ⅲ group than those in grade Ⅰ/Ⅱ group (P<0.01). Pearson correlation analysis showed that the levels of LVEF and 6MWD in CHF patients were positively correlated with the levels of FVC, FEV1, FEV1/FVC, TLC and DLCO, while the levels of LVEDD, LVESD, LAD, NT-proBNP, TNT were negatively correlated with the levels of FVC, FEV1, FEV1/FVC, TLC and DLCO (P<0.05). Conclusions The elderly patients with stable CHF present with decline in cardiopulmonary function and exercise endurance, which are significantly correlated with the severity of cardiac dysfunction.

Key words: chronic heart failure, aged, cardiopulmonary function, exercise endurance, N-terminal pro-brain natriuretic peptide, troponin T

CLC Number:

R 541.61

LU Hao, DENG Hui, WANG Chun, DAI Yang, WANG Qin, WANG Qing. Characteristics of cardiopulmonary function, exercise endurance, and the levels of NT-proBNP and TNT in elderly patients with stable chronic heart failure[J]. Practical Geriatrics, 2023, 37(11): 1138-1142.

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Characteristics of cardiopulmonary function, exercise endurance, and the levels of NT-proBNP and TNT in elderly patients with stable chronic heart failure

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