多配体蛋白聚糖-1早期水平变化对老年脓毒症病人临床转归的预测价值

doi:10.3969/j.issn.1003-9198.2023.10.006

Abstract

Abstract: Objective To investigate the predictive value of syndecan-1(SDC-1) for the prognosis in the elderly patients with sepsis. Methods A total of 102 elderly patients with sepsis in Department of Critical Medicine of our hospital from May 2021 to June 2022 were enrolled. Among them, 44 cases survived (survive group) and 58 cases died (death group) within 28 days. Acute Physiology and Chronic Health Evaluation (APACHEⅡ) and Sequential Organ Failure Assessment (SOFA) were used to evaluate the severity of disease. The levels of lactate (Lac), procalcitonin (PCT), heparin-binding protein (HBP), white blood cell (WBC), neutrophil percentage (N%), platelet (PLT), SDC-1 and the decrease of syndecan-1 (ΔSDC-1) in three days were observed and compared between the two groups. Multivariate Logistic regression analysis was used to explore the risk factors of the prognosis. The receiver operating characteristic (ROC) curve was drawn and the area under the curve (AUC) was calculated to evaluate the predictive value of the influencing factors in the elderly patients with sepsis. Results Compared with survival group, the APACHEⅡscore, SOFA score, and the levels of PCT, HBP, Lac and SDC-1 in death group were significantly increased, and the level of ΔSDC-1 was significantly decreased (P<0.01).ΔSDC-1, SOFA score and APACHEⅡ score were the independent risk factors for 28 d mortality in the elderly patients with sepsis (P<0.05). The ROC curve analysis showed that the predictive value of SOFA score for 28 d death in the elderly patients with sepsis was the highest, followed by ΔSDC-1 level and APACHEⅡ score. Conclusions The dynamic decline level of SCD-1 has a high value in assessing the risk of death in the elderly patients with sepsis.

Key words: sepsis, aged, syndecan-1, prognosis

CLC Number:

R 631.2

CHEN Cheng, CUI Jing, JI Xiao-qi, YAO Li. Predictive value of early changes of syndecan-1 for clinical outcome in elderly patients with sepsis[J]. Practical Geriatrics, 2023, 37(10): 1000-1003.

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Predictive value of early changes of syndecan-1 for clinical outcome in elderly patients with sepsis

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