Practical Geriatrics ›› 2022, Vol. 36 ›› Issue (6): 596-600.doi: 10.3969/j.issn.1003-9198.2022.06.012

Previous Articles     Next Articles

Characteristics and analysis of influencing factors of postoperative electrolyte level changes in patients with craniopharyngioma

JIA Heng, LI Jun, WANG Xing-qi, GONG Liang, MIAO Fa-an, FAN Yue-chao   

  1. Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, China
  • Received:2021-08-16 Online:2022-06-20 Published:2022-06-30

Abstract: Objective To investigate the change characteristics of early postoperative electrolyte level in the patients with craniopharyngioma and to analyze the influencing factors. Methods The data of the cases of craniopharyngioma receiving surgery in the Affiliated Hospital of Xuzhou Medical University from 2011 to 2020 were analyzed retrospectively. According to the age, the patients were divided into elderly group (14 cases), middle-aged group (25 cases) and youth group (43 cases). The changes of electrolyte and thyroid hormone levels in different age groups before and one day after surgery were compared, and the correlations were also analyzed. Results There was significant difference in gender among the three groups (P=0.042), and there were no significant differences in tumor classification and surgical approach (P>0.05). The patients with craniopharyngioma in this study mainly showed hypernatremia, hypocalcemia, hypokalemia and hyperchloremia one day after surgery. There were no significant changes in the levels of all electrolytes in the elderly group after operation(P>0.05). One day after surgery, the levels of potassium and calcium in youth group and the levels of potassium and phosphorus in middle-aged group were significantly decreased, and the differences were statistically significant (all P<0.05). After operation, the levels of free triiodothyronine (FT3) and hypersensitive thyrotropin (sTSH) in the three groups were significantly lower than those before operation, and the level of free thyroxine (FT4) in youth group was significantly lower than that before surgery, and that in middle-aged group and elderly group.Correlation analysis showed that the level of chloride changed was negatively correlated with the level of FT4 changed (r=-0.251, P=0.035), and the level of phosphorus changed was positively correlated with the level of FT3 changed (r=0.281, P=0.020). Conclusions The levels of the electrolytes fluctuate little in the elderly patients with craniopharyngioma one day after surgery, and a personal management of pituitary stalk in the surgery is necessary. Electrolyte monitoring and hormone replacement therapy should be performed well after surgery.

Key words: craniopharyngioma, surgery, aged, electrolyte, thyroid hormone

CLC Number: