血清基质细胞衍生因子-1、趋化因子CCL21与老年急性冠脉综合征病人临床预后的关系

doi:10.3969/j.issn.1003-9198.2022.06.011

Abstract

Abstract: Objective To investigate the predictive value of serum stromal cell-derived factor-1 (SDF-1) and chemokine CCL21 for the clinical prognosis of the elderly patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Methods The clinical data of 186 elderly patients with ACS who received PCI in our hospital from 2016 to 2018 were retrospectively analyzed. According to the occurrence of major adverse cardiovascular events (MACE) during 1-year follow-up, the patients were divided into poor prognosis group (86 patients with MACE) and good prognosis group (100 patients without MACE). The serum levels of SDF-1 and CCL21 were measured by enzyme-linked immunosorbent assay (ELISA). The risk factors for poor prognosis of the elderly patients were analyzed by multivariate Logistic regression. Receiver operating characteristic(ROC) curve was drawn to evaluate the diagnostic value of serum SDF-1 and CCL21 for the short-term poor prognosis of the elderly ACS patients after PCI. Results There were significant differences in the levels of heart rate, left ventricular ejection fraction (LVEF), SDF-1, CCL21, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), troponin and N-terminal pro-B type natriuretic peptide (NT-proBNP), the prevalence of hypertension and the score of GRACE scale between the two groups (P<0.05 or 0.01). Multivariate Logistic regression analysis showed that LVEF, GRACE score, SDF-1 and CCL21 were the independent influencing factors for poor prognosis in the elderly patients. The area under the ROC curve of serum SDF-1 combined with CCL21 in predicting short-term poor prognosis of the elderly patients was 0.930, with a sensitivity and a specificity of 0.841 and 0.857, respectively. Conclusions Serum SDF-1 and CCL21 are the independent influencing factors for short-term poor prognosis of the elderly ACS patients after PCI. The combination of the two indicators has a high predictive value for clinical prognosis in the elderly patients with ACS.

Key words: stromal cell-derived factor-1, chemokine CCL21, acute coronary syndrome, prognosis, aged

CLC Number:

R 543.3

LI Ya-yun. Relationship between serum stromal cell-derived factor-1, chemokine CCL21 and clinical prognosis in elderly patients with acute coronary syndrome[J]. Practical Geriatrics, 2022, 36(6): 592-595.

References

[1] ÇIMCI M, KARADAG B.Acute coronary syndromes in the elderly[J]. Turk Kardiyol Dern Ars, 2017, 45(Suppl 5):35-38.
[2] 李丹.血清胱抑素C与ACS患者PCI术后主要不良心血管事件的关系[J]. 心血管康复医学杂志, 2019, 28(4):437-441.
[3] NISHIGAKI A, TSUZUKI-NAKAO T, KIDO T, et al.Concentration of stromal cell-derived factor-1 (SDF-1/CXCL12) in the follicular fluid is associated with blastocyst development[J]. Reprod Med Biol, 2018, 18(2):161-166.
[4] 邓立菊, 刘庆, 白焱, 等.冠心病患者外周血单个核细胞EPC百分比及SDF-1、VEGF-2水平变化及意义[J]. 山东医药, 2017, 57(12):77-79.
[5] 张正伟, 刘明, 李璐斐, 等.趋化因子CCL2 1对急性冠状动脉综合征的临床预测价值[J]. 中华老年医学杂志, 2017, 36(4):403-407.
[6] 中国医师协会急诊医师分会, 中华医学会心血管病学分会, 中华医学会检验医学分会.急性冠脉综合征急诊快速诊疗指南[J]. 中华急诊医学杂志, 2016, 25(4):397-404.
[7] 钱昊, 汤成春, 鄢高亮.急性冠脉综合征患者血清总胆红素水平与预后的关系研究[J]. 东南大学学报(医学版), 2019, 38(3):406-411.
[8] 王翎翎, 马国娣, 林平.急性冠脉综合征患者PCI术后心脏不良事件发生情况及其影响因素分析[J]. 中华现代护理杂志, 2016, 22(30):4311-4315.
[9] 张晶, 钟诚, 欣明花.血清血小板因子4、CXCL12水平与急性冠状动脉综合征患者预后的相关性分析[J]. 广东医学, 2021, 42(3):298-302.
[10] 季鹏, 孙伟, 贾玉卿.IL-16联合GRACE出院评分对老年非ST段抬高型急性冠状动脉综合征病人不良心脑血管事件的预测价值[J]. 实用老年医学, 2021, 35(9):939-942,947.
[11] 高静, 李晓岚, 王敏哲, 等.血管内皮生长因子、基质细胞衍生因子-1基因对人微血管内皮细胞增殖、迁移、凋亡的影响[J]. 安徽医药, 2019, 23(9):1784-1789.
[12] FERDOUSIE V T, MOHAMMADI M, HASSANSHAHI G, et al.Serum CXCL10 and CXCL12 chemokine levels are associated with the severity of coronary artery disease and coronary artery occlusion[J]. Int J Cardiol, 2017, 233:23-28.
[13] PEIRO O M, FARRE N, CEDIEL G, et al.Stromal cell derived factor-1 and long-term prognosis in acute coronary syndrome[J]. Biomark Med, 2019, 13(14):1187-1198.
[14] CAIDAHL K, HARTFORD M, RAVN-FISCHER A, et al.Homeostatic chemokines and prognosis in patients with acute coronary syndromes[J]. J Am Coll Cardiol, 2019, 74(6):774-782.

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Relationship between serum stromal cell-derived factor-1, chemokine CCL21 and clinical prognosis in elderly patients with acute coronary syndrome

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