Abstract: Objective To investigate the predictive value of the serum levels of amyloid A (SAA) and C1q/tumor necrosis factor associated protein (CTRP) 9 for cardiovascular adverse events in the elderly patients with type 2 diabetes mellitus(T2DM). Methods A total of 110 elderly T2DM patients who received blood glucose control and management in our hospital from April 2016 to April 2019 were selected as the research subjects. All the patients were followed up regularly for 2 years, and the occurrence of adverse cardiovascular events (acute coronary syndrome, arrhythmia, acute heart failure, etc.) was recorded. All patients were divided into the occurrence group and the non-occurrence group. The basic data, laboratory indexes and serum levels of SAA and CTRP9 at admission were compared between the two groups. The risk factors of cardiovascular adverse events in the patients were analyzed by multiple Logistic regression; The receiver operating characteristic (ROC) curve was drawn to analyze the value of serum SAA and CTRP9 alone and combined in predicting the risk of cardiovascular adverse events in the patients; The correlation between SAA and CTRP9 was described by Spearman correlation coefficient. Results Among 110 elderly patients with T2DM, 31 cases had cardiovascular adverse events, with an incidence rate of 28.18%. Compared with the non-occurrence group, the level of SAA was higher, and the level of CTRP9 was lower in the occurrence group, with statistically significant differences (P<0.01). Multivariate Logistic regression analysis showed that the high expression of SAA and the low expression of CTRP9 at admission were risk factors for the occurrence of cardiovascular adverse events in the elderly T2DM patients. ROC curve analysis showed that the area under curve of serum SAA and CTRP9 alone and in combination to predict the risk of cardiovascular adverse events in the elderly T2DM patients was 0.842, 0.815, 0.883, respectively. Spearman correlation analysis showed that there was a negative correlation between SAA and CTRP9 (r=-0.316, P=0.001). Conclusions The serum levels of SAA and CTRP9 at admission have certain predictive value for the incidence of cardiovascular adverse events in the elderly patients with T2DM, and the predictive value of their combination is the highest.

Key words: aged, type 2 diabetes mellitus, amyloid A, C1q/tumor necrosis factor related protein 9, cardiovascular adverse events