老年子宫内膜癌病人血清热休克蛋白70、内脂素、糖类抗原724水平及临床意义

doi:10.3969/j.issn.1003-9198.2022.06.008

Abstract

Abstract: Objective To investigate the serum levels and clinical significance of heat shock protein 70 (HSP70), visfatin and carbohydrate antigen 724 (CA724) in the elderly patients with endometrial cancer. Methods A total of 125 elderly patients with endometrial cancer admitted to our department from December 2018 to March 2021 were selected as endometrial cancer group.Another 100 healthy elderly people were selected as control group.The serum levels of HSP70, visfatin and CA724 were detected and compared between the two groups.The levels of HSP70, visfatin, CA724 of different clinicopathological characteristics groups of the elderly patients with endometrial cancer were compared. The diagnostic efficiency of HSP70, visfatin, CA724 alone and combination of the three indexes for endometrial cancer was analyzed by receiver operating characteristic (ROC) curve. Results The serum level of HSP70 in endometrial cancer group was lower than that in control group, and the serum levels of visfatin and CA724 were higher than those in control group, with statistically significant differences (P<0.01). There were significant differences in serum levels of HSP70, visfatin and CA724 in the patients with different TNM stages, tumor tissue differentiation degree, and lymph node metastasis (P<0.05). ROC curve analysis showed that the combination of HSP70, visfatin and CA724 had an area under the curve of 0.878 for the diagnosis of endometrial cancer, and the sensitivity and specificity was 0.872 and 0.824, respectively, which were higher than the parameters alone. Conclusions The changes of serum HSP70, visfatin and CA724 levels are related to the occurrence and development of endometrial cancer in the elderly. The combined detection of the three indicators is expected to become a new biomarker for predicting and diagnosing endometrial cancer in the elderly.

Key words: heat shock protein 70, visfatin, carbohydrate antigen 724, endometrial cancer, aged

CLC Number:

R 737.33

HU Meng, NIU San-qiang, CHEN Yan, LIU Ning. Clinical significance of heat shock protein 70, visfatin and carbohydrate antigen 724 in elderly patients with endometrial cancer[J]. Practical Geriatrics, 2022, 36(6): 580-583.

References

[1] 陈红敏, 罗艳林, 高玲, 等. 血清糖类抗原 125 与血管内皮生长因子联合检测对子宫内膜癌的诊断价值及临床意义[J]. 癌症进展, 2019, 17(6):722-726.
[2] OGAME N, HORI S, YANO M, et al. Preponderance of endometrial carcinoma in elderly patients[J]. Mol Clin Oncol, 2018, 9(3):269-273.
[3] HEIDARI F, RABIZADEH S, SADAT SALEHI S, et al. Serum HSP70 level in patients with endometrial cancer with and without diabetes[J]. Gynecol Endocrinol, 2019, 36(4):351-355.
[4] 田文艳, 王颖梅, 张艳芳, 等. 脂肪因子内脂素与恶性肿瘤关系的研究现状及展望[J]. 中华肿瘤杂志, 2017, 39(5):321-324.
[5] 刘玲, 李春梅, 杨晓丽, 等. PDCA循环在提高医院内感染管理质量中的效果分析[J]. 中华医院感染学杂志, 2017, 27(3):685-687,698.
[6] TALHOUK A, MCCONECHY M K, LEUNG S, et al. Confirmation of ProMisE: a simple, genomics-based clinical classifier for endometrial cancer[J]. Cancer, 2017, 123(5):802-813.
[7] 闫巧辉, 邢国臣, 潘琼. 恶性肿瘤特异生长因子和肿瘤浸润性树突状细胞在子宫内膜癌患者中的表达及临床意义[J]. 现代肿瘤医学, 2019, 27(5):845-848.
[8] FENG J, ZHAN Y T, ZHANG Y T, et al. Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma[J]. Cancer Manag Res, 2019, 11:8219-8227.
[9] ROTHAMMER A, SAGE E K, WERNER C, et al. Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy-potential markers for predicting breast cancer recurrence[J]. Radiat Oncol, 2019, 14(1):78.
[10] 王鑫, 王钊, 李元春, 等. 热休克蛋白70及基质金属蛋白酶-7和EHD2蛋白在结直肠癌组织中的表达及意义[J]. 新乡医学院学报, 2019, 36(5):443-447.
[11] 王巍, 刘晓宇. 十二指肠肿瘤切除术围手术期患者血清胃蛋白酶和热休克蛋白70水平的变化及其临床意义[J]. 中国现代医学杂志, 2019, 29(6):77-82.
[12] TABARI Z A, KESHANI F, SHARBATDARAN M, et al. Visfatin expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: an immunohistochemical analysis[J]. Dent Res J, 2018, 15(2):104-110.
[13] ZHANG L J, LI X Q, WANG C D, et al. The correlation of visfatin and its gene polymorphism with non-small cell lung cancer[J]. Cancer Biother Radiopharm, 2018, 33(10):460-465.
[14] CYMBALUK-PŁOSKA A,CHUDECKA-GŁAZ A,PIUS-SADOWSKA E,et al.Circulating serum level of visfatin in patients with endometrial cancer[J]. Biomed Res Int,2018. DOI: 10.1155/2018/8576179.
[15] 刘彦合, 宋杰峰, 李慧, 等. 血清肿瘤标志物CEA、CA19-9、CA242及CA724联合检测在胃癌诊断中的价值分析[J]. 现代消化及介入诊疗, 2019, 24(4):416-420.
[16] 刘应玲, 陈思, 洪海鸥, 等. 血清胃蛋白酶原、胃泌素17和幽门螺杆菌检测在胃癌前病变诊断中的价值[J]. 安徽医科大学学报, 2017, 52(8):1227-1231.
[17] BIAN J, SUN X, LI B, et al. Clinical significance of serum HE4, CA125, CA724, and CA19-9 in patients with endometrial cancer[J]. Technol Cancer Res Treat, 2017, 16(4):435-439.

Clinical significance of heat shock protein 70, visfatin and carbohydrate antigen 724 in elderly patients with endometrial cancer

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