Abstract: Objective To compare the intervention effect of pneumonia vaccine and influenza vaccine on respiratory diseases in the elderly patients with chronic diseases. Methods From August 2017 to August 2019, a total of 150 elderly patients with chronic diseases(aged ≥ 60 years) who met the vaccination criteria were vaccinated in the Preventive Medicine Outpatient Department of Jiangsu Provincial Center for Disease Control and Prevention. They were divided into 3 groups according to the vaccination orders. Of them, 50 cases in pneumonia vaccine group were only inoculated with pneumonia vaccine, 50 cases in influenza vaccine group were only inoculated with influenza vaccine, while 50 cases in combined vaccination group were inoculated with both vaccines. The treatment and hospitalization, the occurrence rate of adverse reactions, pneumonia and influenza were compared among the three groups. Results Compared with pneumonia vaccine group and influenza vaccine group, the combined inoculation group had more reduced numbers of visit, hospitalization and shorter duration of hospitalization (all P<0.05). The difference of total adverse reaction incidence was not significant among the three groups(P＞0.05). The incidence of pneumonia in the pneumonia vaccine group and the combined inoculation group was lower than that in the influenza vaccine group (P<0.05); While the incidence of influenza in the influenza vaccine group and the combined inoculation group was lower than that in the pneumonia vaccine group (P<0.05). Conclusions The combined inoculation of pneumonia vaccine and influenza vaccine can significantly reduce the visiting rate and hospitalization rate of respiratory system diseases among the elderly patients with chronic diseases, which can shorten the hospitalization duration and prevent the occurrence of pneumonia and influenza effectively with low adverse reaction rate.

Key words: pneumonia vaccine, influenza vaccine, combined vaccination, aged, chronic disease, intervention effect