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20 December 2021, Volume 35 Issue 12 Previous Issue    Next Issue

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Efficacy of intensity modulated radiation therapy with concurrent chemotherapy of tegafur for the elderly patients with esophageal cancer: a phase Ⅱ clincal trial ZHANG Zhi, ZHOU Guo-ren, YE Jin-jun, GU Da-yong, LI Hui, CHEN Wei, FANG Ying, CHEN Cheng, QIAN Pu-dong, TAO Hua, ZHU Xiang-zhi, LU Jin-cheng 2021, 35 (12):  1232-1235.  doi: 10.3969/j.issn.1003-9198.2021.12.006 Abstract ( 191 )   PDF (1070KB) ( 970 )   Save Objective To evaluate the efficacy and toxic effects of intensity modulated radiation therapy(IMRT) combined with tegafur(S-1) in the elderly patients with esophageal cancer. Methods This was a single-arm, phase Ⅱ clinical study. A total of 120 elderly patients with esophageal squamous cell carcinoma aged ≥75 years old from May 2014 to April 2021 were recruited. The IMRT and chemotherapy were conducted. The adverse reactions and curative effects were observed. Results The median follow-up time was 41.2 months (5.9-90.4 months) by October 2021. One-, two- and three-year overall survival rate was 81.1%, 64.8%, and 48.0%, respectively. One-, two- and three-year progression-free survival rate was 77.6%, 53.4%, and 39.3%, respectively. One-, two- and three-year tumor specific overall survival rate was 88.2%, 78.5%, and 64.1%, respectively. The main toxic and side effects above grade 3 were hematological reactions, including grade 3 hemoglobin decreased in 1 case (0.8%), grade 3 leukocyte decreased in 9 cases (7.5%), grade 4 leukocyte decreased in 2 cases (1.7%), grade 3 granulocyte decreased in 3 cases (2.5%), grade 4 leukocyte decreased in 1 case (0.8%), and grade 3 platelet decreased in 4 cases (3.3%). Conclusions Involving field radiotherapy combined with concurrent chemotherapy with S-1 is safe and effective in the elderly patients with esophageal squamous cell carcinoma, and the toxic and side effects are tolerable. It is worthy of further phase Ⅲ clinical study. References | Related Articles | Metrics

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Effect of new cardiac rehabilitation training on cardiac systolic function in the elderly patients with acute myocardial infarction after percutaneous coronary intervention ZHAO Dong-jing, TANG Wei, CAO Shu-jun, HU Shuo-qiang, YANG Na, TONG Zi-chuan 2021, 35 (12):  1236-1240.  doi: 10.3969/j.issn.1003-9198.2021.12.007 Abstract ( 158 )   PDF (1080KB) ( 1606 )   Save Objective To explore the effect of a new cardiac rehabilitation model on cardiac systolic function in the elderly patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods A prospective research was carried out, and 160 elderly patients with AMI receiving PCI admitted to our hospital from May 2017 to May 2019 were enrolled.The patients were divided into observation group and control group by random number table, with 80 cases in each group.The control group received routine rehabilitation training, while the observation group received new cardiac rehabilitation training. The changes of cardiac function in the two groups were measured before intervention and 3 months after intervention, including left atrial diameter (LAD), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic volume (LVESV), wall motion score index (WMSI), and left ventricular end-diastolic volume (LVEDV).The symptoms of angina pectoris was evaluated by Seattle Angina Questionnaire (SAQ) before and after intervention, and the adverse events were recorded in both groups. Results After intervention, the level of LVEF of the two groups was higher and the levels of LVESV, WMSI and LVEDV were lower than those before intervention(P<0.05), especially in the observation group (P<0.05).After intervention, the frequency of angina attack, the degree of angina stability, the satisfaction of treatment, the limitation of physical activity and the score of disease recognition in the two groups were higher than those before intervention, especially in the observation group (P<0.05 or P＜0.01).There was no difference in the incidence rate of heart failure, shock, arrhythmia and mortality between the two groups (P>0.05). Conclusions The new cardiac rehabilitation model can promote the improvement of cardiac function in the elderly patients with AMI and further alleviate the symptoms of angina pectoris, which is worthy of popularization and application. References | Related Articles | Metrics

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Evaluation of reliability and validity of the Chinese version of HB-HBP scale in assessing the compliance of elderly patients with hypertension HAN Dan, NIE Li, WANG Mei-hua, SUN Jing, CAI Jun, LI Fu-chao 2021, 35 (12):  1241-1245.  doi: 10.3969/j.issn.1003-9198.2021.12.008 Abstract ( 217 )   PDF (1098KB) ( 1099 )   Save Objective To translate the English version of Hill-Bone Compliance to High Blood Pressure Therapy (HB-HBP) Scale into Chinese, and then assess the reliability and validity of HB-HBP scale in evaluating the compliance in the elderly patients with hypertension. Methods HB-HBP scale was translated into Chinese with the cultural modification. A total of 242 elderly patients with hypertension were recruited for the assessment of reliability and validity. Results Cronbach’s α coefficient of HB-HBP scale was 0.744 and the test-retest reliability was 0.811. The item-content validity index(I-CVI)value of each item was 0.833-1.000, and scale-content validity index(S-CVI)value was 0.944. The exploratory factor analysis revealed that KMO factor was 0.976 and the cumulative variance contribution rate was 69.31%. The confirmatory factor analysis showed that the average variance extracted (AVE) values were higher than 0.5, composite reliability (CR) values were higher than 0.7, and all the standardized loading coefficients were higher than 0.7 in the three dimensions of HB-HBP scale(P<0.001). Conclusions HB-HBP scale is suitable to assess the treatment compliance of the elderly patients with hypertension in China with high reliability and validity. References | Related Articles | Metrics

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Correlation between SYNTAX score and edge time cardiovascular risk in elderly patients receiving OPCAB JIAO Hui-hui, ZHANG Jian-ying, FENG Jian-ping, GUAN Yu-zhen 2021, 35 (12):  1246-1248.  doi: 10.3969/j.issn.1003-9198.2021.12.009 Abstract ( 124 )   PDF (1044KB) ( 985 )   Save Objective To investigate the correlation of edge time (ET)cardiovascular risk and SYNTAX score in the elderly patients receiving off-pump coronary artery bypass (OPCAB). Methods A retrospective analysis was performed on 650 elderly patients who received OPCAB in our hospital from January 2019 to December 2020. They were divided into group A (n=319) with low and moderate SYNTAX score and group B (n=331) with high SYNTAX score. The correlation between the major cardiovascular adverse events (MACE)and SYNTAX score was analyzed. Results The incidence rate of angina(10.3% vs 3.4%,P＜0.05), malignant arrhythmia(4.2% vs 0.9%,P＜0.05)and MACE(21.1% vs 6.5%,P＜0.05)in group B was significantly higher than that in group A.The percentage of the patients receiving intra-aortic ballooncounterpulsation(IABP) (6.0%vs 1.9%,P＜0.05) and extracorporeal membrace oxygenation(ECMO) (3.6% vs 0.9%,P＜0.05 )in group B was higher than that in group A. Conclusions The patients with high level of SYNTAX score are more likely to suffer from MACE at ET of OPCAB. References | Related Articles | Metrics

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Study on the relationship between fall risk and geriatric syndrome in community elderly BIAN Meng, FENG Qing-qing, DU Yu-feng 2021, 35 (12):  1249-1253.  doi: 10.3969/j.issn.1003-9198.2021.12.010 Abstract ( 154 )   PDF (1083KB) ( 2427 )   Save Objective To investigate the prevalence of geriatric syndrome and the incidence of falls among the elderly in community, and to explore the related risk factors of falls. Methods Using cluster random sampling, 90 cases were selected from each of the six communities in Taiyuan. There were 540 cases included. And the subjects received the assessment of self-designed manual, including the general sociodemographic characteristics, the prevalence of chronic diseases, and the common senile syndromes. The relationship between the results of the assessment and the occurrence of falls in the community elderly in the past 2 years was analyzed. Results The incidence of falls within 2 years in 513 elderly people in the community was 25.1%. Single factor analysis showed that gender, age, number of chronic diseases, living environment, pain degree, vision status, nutritional status, insomnia status, ability of daily living, 5 sit-ups test, 3-meter rise-walking test were associated with the incidence of fall among elderly in communities (P<0.05); The results of multivariate analysis showed that age[OR(95%CI)=1.856(1.123-3.068)], obesity [OR(95%CI)=2.772(1.349-5.695)], severe disability of daily living [OR(95%CI)=3.045(1.168-7.940)], the number of chronic diseases[OR(95%CI)=1.615(1.026-2.542)], visual acuity[OR(95%CI)=3.139(1.256-7.842)], and suspicious insomnia and insomnia [OR(95%CI)=1.900(1.055-3.421), 2.501(1.428-4.381)] were the independent factors influencing the occurrence of fall in the elderly in community (P<0.05). Conclusions The incidence of fall is high in the elderly. Age≥70 years old, obesity, the number of chronic diseases≥ 2, severe dysfunction of the ability of daily living, visual impairment affecting normal life, suspicious insomnia and insomnia can increase the risk of fall in the elderly in community. References | Related Articles | Metrics

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Effects of exercise intervention during dialysis on quality of life and sleep quality in elderly patients receiving maintenance hemodialysis under the model of multi-disciplinary team XIA Jing-hua, SONG Dan, ZHU Wen-bo, ZHOU Yue 2021, 35 (12):  1254-1257.  doi: 10.3969/j.issn.1003-9198.2021.12.011 Abstract ( 158 )   PDF (1070KB) ( 1207 )   Save Objective To explore the improvement effect of exercise intervention during dialysis on quality of life and sleep quality in the elderly patients receiving maintenance hemodialysis under the model of multi-disciplinary team. Methods A total of 68 patients were randomly divided into two groups with 34 cases in each group, the experimental group receiving multi-disciplinary team intervention and the control group receiving the duty nurse on dialysis day intervention. They were given exercise intervention for 6 months. The scores of life quality investigated by Chinese version of SF-36 Health Survey Scale, and sleep quality investigated by Pittsburgh Sleep Quality Scale, PSQI of the two groups were compared 1, 3 and 6 months after intervention. Results At the end of intervention, the number of patients in the experimental group and the control group who completed the intervention was 32 and 29, respectively. After 1, 3 and 6 months of intervention, the scores of PSQI of the two groups were gradually and significantly decreased; The scores of physical component summary(PCS)and mental component summary(MCS)of the experimental group were gradually and significantly increased (P<0.05), while in the control group, the score of PCS 3, 6 months after intervention was significantly higher than that of 1 month affter intervention, the score of MCS 6 months after intervention was significantly higher than that 1, 3 months after intervention. After 6 months of intervention, PCS and MCS scores of the experimental group were significantly higher than those of the control group (P<0.05). 3 and 6 months after intervention, PSQI score of the experimental group was significantly lower than that of the control group(P<0.05). Conclusions The multi-disciplinary team model can reduce patients’ withdrawal from exercise intervention, and has a better middle and long term effect on the quality of life and sleep quality than the nurse intenvention model. References | Related Articles | Metrics

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Correlation of serum levels of 25OHD and parathyroid hormone with prognosis of elderly patients with osteoporosis receiving total hip arthroplasty ZHANG Zhi-shui, WEI Zhi-ling, WANG Yu-jing, Cui Peng 2021, 35 (12):  1258-1261.  doi: 10.3969/j.issn.1003-9198.2021.12.012 Abstract ( 174 )   PDF (1069KB) ( 1018 )   Save Objective To investigate the correlation between the serum level of 25-hydroxyvitamin D (25OHD), parathyroid hormone (PTH) and the prognosis of total hip arthroplasty (THA) in the elderly patients with osteoporosis (OP). Methods The clinical data of 147 hip fracture patients who underwent THA surgery in our hospital from October 2017 to October 2019 were retrospectively analyzed. Bone mineral density (BMD) examination was performed before operation, and 117 patients were diagnosed as OP. Six months after surgery, the OP patients was divided into good prognosis group (89 cases) and poor prognosis group (28 cases) according to Harris score. The general clinical data and biochemical indicators including 25OHD, PTH of the two groups were compared. The multivariate Logistic regression analysis was used to analyze the independent risk factors affecting the prognosis of THA in the elderly patients with OP. The correlation between serum levels of 25OHD, PTH and Harris score was analyzed by Pearson correlation. Results The age, postoperative joint dislocation, intraoperative blood loss, and serum level of PTH at admission in the poor prognosis group were higher than those in the good prognosis group, and the BMD, serum level of 25OHD at admission were lower than those in the good prognosis group (P<0.05); Logistic regression showed that old age, postoperative joint dislocation, low serum level of 25OHD and high serum level of PTH at admission were independent risk factors that affecting the prognosis of THA in the elderly patients with OP (OR=3.785, 5.652, 1.657, 3.271). Pearson analysis showed that BMD and 25OHD level were positively correlated with Harris score (r=0.621, 0.764), and PTH level was negatively correlated with Harris score (r=-0.557). Conclusions Low serum level of 25OHD and high serum level of PTH are independent risk factors affecting the prognosis of the elderly patients with OP after THA, and can be used as reference indicators for predicting the prognosis of the elderly patients with OP after THA. References | Related Articles | Metrics

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Value of circulating follicular helper T cells in elderly patients with T-cell lymphoma infection ZHENG Fei-fei, ZHU Lan, SHEN Wei-hong 2021, 35 (12):  1262-1264.  doi: 10.3969/j.issn.1003-9198.2021.12.013 Abstract ( 176 )   PDF (1175KB) ( 925 )   Save Objective To investigate the changes of circulating follicular helper T (cTfh) cells in the elderly patients with T-cell lymphoma. Methods A total of 55 patients with T-cell lymphoma, 55 healthy controls and 55 patients treated with drugs were recruited in the study. The molecular markers (CD134) related to the surface of cTfh cells in each group were detected by the latest flow cytometry. The expression of interleukin (IL)-4, IL-21 secreted by the molecular markers related to the surface of cTfh cells in each group was detected and compared. Results The results of flow cytometry analysis showed that the proportion of CD134 in peripheral blood of the patients with T-cell lymphoma was higher than that of health control group and drug treatment group (P<0.05). The levels of serum IL-21 and IL-4 in the drug treatment group were significantly lower than those in the T-cell lymphoma group, but still higher than those in the healthy control group (P<0.05). Conclusions CTfh cells and cytokines may play an important role in the pathogenesis of immune response in the elderly patients with T-cell lymphoma. References | Related Articles | Metrics

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Oral nutrition supplementation in the elderly patients with cognitive frailty YU Pei-wen, BAO Hai-tong, CHEN Xing, TAN Ping, CHEN Shu, MAO Yan, TONG Qiang-wei 2021, 35 (12):  1265-1268.  doi: 10.3969/j.issn.1003-9198.2021.12.014 Abstract ( 193 )   PDF (1063KB) ( 974 )   Save Objective To explore the effect of oral nutritional supplement (ONS) therapy in the elderly patients with cognitive frailty (CF). Methods Eighty elderly patients with CF were randomly divided into intervention group and control group, with 40 cases in each group. The control group was given regular diet, the intervention group was given ONS on the basis of control group. Before the intervention and 6 months after the intervention, the serum levels of nutritional indicators including transferrin (TRF), albumin (ALB), prealbumin (PAB), hemoglobin (Hb) were detected, the Mini Nutritional Assessment Scale (MNA), Mini-Mental State Examination (MMSE), Fried Frailty Phenotype (PFP), Frailty Index based on comprehensive geriatric assessment (FI-CGA) scores were evaluated, the walking speed and triceps skin fold thickness (TSF) were measured. Results After 6 months of the intervention, the serum levels of TRF, ALB, PAB, Hb, MNA score, MMSE score and TSF of the intervention group were significantly increased, PFP and FI-CGA scores were significantly decreased than those before intervention(P<0.05 or P<0.01 ), while in the control group, there were no significant differences of the above indexes(P>0.05). After 6 months of the intervention, the above indexes of the intervention group were significant improved than those in the control group (P<0.05). Conclusions ONS therapy can improve the nutritional status and cognitive function of the elderly patients with CF, reduce weakness and fatigue, and enhance physical functions. It is recommended that elderly patients with CF implement ONS appropriately. References | Related Articles | Metrics

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Expression and clinical significance of serum OX40 and OX40 ligand in the elderly patients with acute cerebral infarction SHI Yan, ZANG Yan-jing, WANG Su-yu, LIU Shu-li 2021, 35 (12):  1269-1272.  doi: 10.3969/j.issn.1003-9198.2021.12.015 Abstract ( 170 )   PDF (1069KB) ( 1255 )   Save Objective To explore the expression and clinical significance of serum OX40 and OX40 ligand (OX40L) in the elderly patients with acute cerebral infarction. Methods A total of 146 elderly patients with acute cerebral infarction (observation group) and 50 healthy elderly (control group) in our hospital from January 2018 to December 2019 were selected, and the serum levels of OX40 and OX40L were detected. The National Institutes of Health Stroke Scale (NIHSS) was used to evaluate the neurological impairment, and the patients with acute cerebral infarction were divided into mild impairment group (n=32), moderate impairment group (n=72) and severe impairment group (n=42) according to the NIHSS scores. Three months after discharge, the modified Rankin Scale (mRS) was used to evaluate the prognosis of the elderly patients with cerebral infarction, and the patients were divided into good prognosis group (n=97) and poor prognosis group (n=49). Pearson test and Logistic regression were used for correlation analysis. Receiver operating characteristic (ROC) curve was drawn to analyze the prognostic value of serum OX40 and OX40L. Results The levels of serum OX40 and OX40L in mild impairment group, moderate impairment group and severe impairment group were higher than those in the control group (P<0.05); The levels of OX40 and OX40L increased with the increasing severity of the disease(P<0.05). NIHSS scores were positively correlated with the levels of OX40 and OX40L (r were 0.578 and 0.701 respectively, P＜0.05). The levels of serum OX40 and OX40L in the poor prognosis group were higher than those in the good prognosis group (P<0.05). Multivariate Logistic regression analysis showed that OX40 and OX40L were the independent risk factors for the prognosis of the elderly patients with acute cerebral infarction (P<0.05).ROC curve showed that the AUC of OX40 and OX40L for predicting the prognosis of patients was 0.793 and 0.854, respectively. The combined detection of the two indexes could increase the AUC to 0.914. Conclusions OX40 and OX40L are related to the severity of neurological deficit in the elderly patients with acute cerebral infarction, and can be used to predict the early clinical prognosis. References | Related Articles | Metrics

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Diagnostic value of peripheral blood urothelial carcinoma antigen 1 and lipoprotein (a) in elderly patients with acute myocardial infarction CUI Juan, ZHENG Jun-chen 2021, 35 (12):  1273-1276.  doi: 10.3969/j.issn.1003-9198.2021.12.016 Abstract ( 138 )   PDF (1123KB) ( 978 )   Save Objective To investigate the diagnostic value of urothelial carcinoma antigen 1(UCA1) and lipoprotein (a) (Lpa) in the elderly patients with acute myocardial infarction(AMI). Methods One hundred elderly patients with AMI in our hospital from February 2018 to February 2020 were selected as the observation group, and another 100 healthy subjects receiving normal physical examination in the same period were selected as the control group. The gender, age, course of disease, body mass index(BMI), systolic blood pressure(SBP), diastolic blood pressure(DBP), smoking history, diabetes history, hyperlipidemia history, the levels of high density lipoprotein cholesterol(HDL-C), total cholesterol(TC), triglyceride(TG), homocysteine(Hcy), creatine kinase isoenzyme(CK-MB), troponin I(cTnI), UCA1, Lpa and low density lipoprotein cholesterol(LDL-C) were collected and compared. Logistic regression analysis was used to analyze the risk factors, and ROC curve was drawn to determine the diagnostic value of the risk factors. Results There were no significant differences in gender, age, course of disease, BMI, SBP and DBP between the two groups (P>0.05). The proportion of smoking, diabetes and hyperlipidemia in the observation group were significantly higher than those in the control group (P<0.05). There were no significant differences in the levels of HDL-C, TC and TG between the two groups (P>0.05). The levels of LDL-C, Hcy, LPA, CK-MB and cTnI in the observation group were significantly higher than those in the control group, while UCA1 was lower than that in the control group (P<0.05) .Logistic regression analysis showed that LPA(OR=2.316,P=0.016), UCA1(OR=3.353,P=0.034), CK-MB(OR=2.270,P=0.046), cTnI(OR=2.075,P=0.043)were the risk factors of AMI in the elderly patients. The cut-off value of LPA for diagnosing AMI was 253.55 mg/L, with a sensitivity of 0.710, with a specificity of 0.690; The cut-off value of UCA1 for diagnosing AMI was 0.11, with a sensitivity of 0.720, with a specificity of 0.700; The cut-off value of CK-MB for diagnosing AMI was 36.34 IU/L, with a sensitivity of 0.740, with a specificity of 0.710; The cut-off value of cTnI for diagnosing AMI was 2.16 ng/L, with a sensitivity of 0.740, with a specificity of 0.720 .The sensitivity, specificity of the combined diagnosis was 0.820, 0.740 respectively. Conclusions The serum levels of LPA, CK-MB, cTnI are significantly increased, and the level of UCA1 is significantly decreased in the elderly patients with AMI. The sensitivity and specificity of the four indexes combined for AMI are high, which have certain clinical value. References | Related Articles | Metrics

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Effect of orthodontics combined with prosthodontics on oral health related quality of life in the elderly patients with dentition defect LU Sheng-nan, SHI Hui，XIA Wen-qian, MIU Jing 2021, 35 (12):  1277-1280.  doi: 10.3969/j.issn.1003-9198.2021.12.017 Abstract ( 157 )   PDF (1063KB) ( 1171 )   Save Objective To investigate the effect of orthodontics combined with prosthodontics on oral health related quality of life (OHRQoL) in the elderly patients with dentition defect. Methods A total of 37 elderly patients with dentition defect were selected and divided into group A(receiving orthodontics combined with prosthodontics ) and group B(receiving prosthodontics) according to the treatment method. Clinical effect and OHRQoL which was evaluated by OHIP-14 before and after treatment were recorded and compared between the two groups. Results There were no significant differences in age, sex between the two groups. The score of pain and discomfort dimension of OHIP-14 in group A was significantly higher than that in group B before treatment. After treatment, the total scores of OHIP-14 and four dimensions were significantly decreased in both groups. Additionally, the change of total scores and pain and discomfort dimension in group A was more significant than that of group B. There was no significant difference in total effect and satisfaction between the two groups. But the masticatory efficiency and expenditure of group A were significantly higher than those in group B. Conclusions Orthodontics combined with prosthodontics can improve the masticatory efficiency and OHRQoL of the elderly patients with dentition defect. Individualized treatment should be performed for the elderly patients with dentition defect. References | Related Articles | Metrics

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Effects of hemoperfusion combined with acupuncture on pruritus in the elderly patients with uremia JIANG Juan-juan, YE Xiao-shuang, JIANG Lu-yue, YANG Juan, YAN Wen-yan, CHEN Yan, XU Ji-min, SUN Shi-zhu 2021, 35 (12):  1281-1283.  doi: 10.3969/j.issn.1003-9198.2021.12.018 Abstract ( 140 )   PDF (1096KB) ( 929 )   Save Objective To investigate the effect of hemoperfusion combined with acupuncture on pruritus in the elderly patients with uremia. Methods The clinical data of 45 cases of elderly uremic patients who received blood purification in Jiangsu Province Geriatric Hospital were collected from January to June 2020. The patients were divided into the hemoperfusion group, hemoperfusion with acupuncture group and control group. The treatment was for 8 weeks. The serum level of urea nitrogen, creatinine, calcium, phosphorus, intact parathyroid hormone(iPTH), high sensitivity C-reactive protein(hs-CRP), interleukin-6(IL-6), visual analogue scale(VAS)and 5-D itch score were recorded before and after the intervention. And the levels of single-pool Kt/V(spKt/V) and urea reduction rate(URR) were calculated. Results There were 42 patients included in this study. Before treatment, there were no significant difference in the levels of urea nitrogen, creatinine, spKt/V, URR, body mass index(BMI), calcium, phosphorus, iPTH, hs-CRP, IL-6, VAS scores and 5-D itch scores among the three groups. The serum levels of phosphorus, iPTH, hs-CRP, IL-6, VAS scores and 5-D itch scores in the hemoperfusion group and the hemoperfusion with acupuncture group were significantly lower than those in the control group after intervention(P＜0.05).The serum levels of phosphorus, hs-CRP, IL-6, VAS scores and 5-D itch scores in the hemoperfusion with acupuncture group were significantly lower than those in the hemoperfusion group after intervention(P＜0.05). Conclusions The effect of hemoperfusion combined with acupuncture on the improvement of pruritus in the elderly patients with uremia is more apparent. References | Related Articles | Metrics

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Comparison of the intervention effect of combination of pneumonia vaccine and influenza vaccine on respiratory diseases in the elderly patients with chronic diseases FENG Xiao-lei, LI Li, ZHU Mei-yu 2021, 35 (12):  1284-1287.  doi: 10.3969/j.issn.1003-9198.2021.12.019 Abstract ( 162 )   PDF (1062KB) ( 4336 )   Save Objective To compare the intervention effect of pneumonia vaccine and influenza vaccine on respiratory diseases in the elderly patients with chronic diseases. Methods From August 2017 to August 2019, a total of 150 elderly patients with chronic diseases(aged ≥ 60 years) who met the vaccination criteria were vaccinated in the Preventive Medicine Outpatient Department of Jiangsu Provincial Center for Disease Control and Prevention. They were divided into 3 groups according to the vaccination orders. Of them, 50 cases in pneumonia vaccine group were only inoculated with pneumonia vaccine, 50 cases in influenza vaccine group were only inoculated with influenza vaccine, while 50 cases in combined vaccination group were inoculated with both vaccines. The treatment and hospitalization, the occurrence rate of adverse reactions, pneumonia and influenza were compared among the three groups. Results Compared with pneumonia vaccine group and influenza vaccine group, the combined inoculation group had more reduced numbers of visit, hospitalization and shorter duration of hospitalization (all P<0.05). The difference of total adverse reaction incidence was not significant among the three groups(P＞0.05). The incidence of pneumonia in the pneumonia vaccine group and the combined inoculation group was lower than that in the influenza vaccine group (P<0.05); While the incidence of influenza in the influenza vaccine group and the combined inoculation group was lower than that in the pneumonia vaccine group (P<0.05). Conclusions The combined inoculation of pneumonia vaccine and influenza vaccine can significantly reduce the visiting rate and hospitalization rate of respiratory system diseases among the elderly patients with chronic diseases, which can shorten the hospitalization duration and prevent the occurrence of pneumonia and influenza effectively with low adverse reaction rate. References | Related Articles | Metrics

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Effect of precision nursing in elderly patients with chronic heart failure complicated with sarcopenia WANG Xu, XU Ling, LIAN Min, ZHANG Jian-wei, WANG Lu-yao, WANG Qin 2021, 35 (12):  1313-1317.  doi: 10.3969/j.issn.1003-9198.2021.12.027 Abstract ( 129 )   PDF (1075KB) ( 1131 )   Save Objective To study the effect of precision nursing in elderly patients with chronic heart failure complicated with sarcopenia. Methods From December 2018 to July 2020, 162 elderly patients with chronic heart failure and sarcopenia admitted to our hospital were selected and randomly divided into control group (82 cases) and research group (80 cases). The control group received conventional nursing intervention for elderly chronic heart failure patients with sarcopenia, and the research group received precision nursing intervention on the basis of the control group. The intervention time was two months. Cardiac functions including left ventricular ejection fraction(LVEF), left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume(LVESV), and muscle grip strength, Minnesota living heart failure questionnaire (MLHFQ) and treatment compliance of the two groups before and after intervention were compared and analyzed. Results After the intervention, the level of LVEF of the two groups was significantly higher than that before intervention, especially in the research group (P<0.05). The levels of LVEDV, LVESV, the scores of different dimensions of MLHFQ and the total MLHFQ score of the two groups were significantly reduced, especially in the research group (P<0.05). The muscle grip of the research group was significantly higher than that of the control group and before intervention (P<0.05). In addition, the treatment compliance rate of the research group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusions Precision nursing can improve the heart and muscle function of the elderly patients with chronic heart failure complicated with sarcopenia, as well as treatment compliance and quality of life. References | Related Articles | Metrics

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Effect of refined specialist nursing on inflammatory factors in elderly patients with diabetes complicated with pulmonary infection DAI Qian, WANG Juan 2021, 35 (12):  1318-1321.  doi: 10.3969/j.issn.1003-9198.2021.12.028 Abstract ( 152 )   PDF (1061KB) ( 1087 )   Save Objective To investigate the effect of refined specialist nursing on inflammatory factors in the elderly patients with diabetes complicated with pulmonary infection. Methods A total of 35 elderly patients with diabetes complicated with pulmonary infection were retrospectively analyzed. They were divided into refined specialist nursing group and routine nursing group by admission order. The clinical data including blood examination, inflammation factors and hospital stay were recorded and compared between the two groups. Results There were no significant differences in sex, age, glycosylated hemoglobin, hypertension, smoking, drinking, the levels of C-reactive protein(CRP), heparin binding protein(HBP), procalcitonin(PCT) between the two groups. Compared with admission, there were no significant differences in the levels of white blood cell, neutrophil, lymph cell, mononuclear cell one week later in the two groups. After intervention, the levels of CRP, HBP of the two groups were significant decreased than those at admission, especially in refined specialist nursing group. The hospital stay of refined specialist nursing group was shorter than that of routine nursing group (P<0.05). Conclusions Refined specialist nursing can reduce the level of inflammation stress of elderly patients with diabetes complicated with pulmonary infection, shorten hospital stay, which is worthy of application. References | Related Articles | Metrics