Abstract: Objective To explore the expression of serum ACT-A in the elderly with different glucose staus. Methods A total of 293 stable patients who underwent physical examination in the VIP department of Ruijin Hospital from July 2022 to February 2023 were enrolled. The serum ACT-A level was detected, and the expression differences of ACT-A in the patients with different clinical characteristics and the influencing factors in the patients with different glucose status were analyzed. Results The level of ACT-A increased with age and the progression of diabetes (P<0.01). The level of ACT-A was higher in elderly diabetic patients with HbA1c≥7%, renal insufficiency, hypertension history, pulse pressure>55 mmHg and pulse pressure index>0.45. In diabetes population, Pearson correlation analysis and linear regression confirmed that the level of ACT-A was positively correlated with age, HbA1c, and HOMA-IR(B=20.996, 33.391, 57.482, P<0.05), and negatively correlated with the level of fasting insulin(B=-17.794, P<0.05). Conclusions The level of ACT-A is positively correlated with age. The level of ACT-A can be increased in the patients with prediabetes, and further increased in the patients with diabetes. Age, HbA1c, HOMA-IR and fasting insulin are independently associated with ACT-A level in diabetic patients.

Key words: activin-A, aged, diabetes mellitus, prediabetes