老年甲状腺良性结节微波消融疗效观察及安全性评价

doi:10.3969/j.issn.1003-9198.2024.03.009

Abstract

Abstract: Objective To investigate the effect of ultrasound-guided percutaneous microwave ablation(MWA) on benign thyroid nodules with different components, and to analyze the effects on thyroid function in the elderly patients. Methods A total of 69 elderly patients (48 females, 21 males, 60-82 years old) with thyroid nodules who received ultrasound-guided MWA in Jiangsu Procince Geriatric Hospital and the First Affiliated Hospital of Nanjing Medical University from January 2015 to March 2018 were retrospectively enrolled. According to the main ablation nodules, the patients were divided into cystic nodules group, solid nodules group and mixed nodules group. All patients were followed up for 1, 3, 6 and 12 months after treatment.The changes of nodule volume reduction rate and thyroid function were detected. Results Twelve months after treatment, 7 patients (10.1%) presented with subclinical hypothyroidism, and 1 patient (1.4%) presented with subclinical hyperthyroidism. The serum level of thyroglobulin in all groups was significantly lower than that before treatment (P<0.01), and the serum levels of antithyroglobulin antibody (TgAb) and anti-thyroid peroxidase antibody(TPOAb) did not change significantly after MWA (P>0.05). At the 12th month of follow-up, the volume reduction rate in cystic nodule patients was 92.91%, compared with 72.55% in solid nodules group and 89.45%in mixed nodules group(P<0.05). Conclusions Ultrasound-guided percutaneous MWA is a safe and effective method for the treatment of benign thyroid nodules in the elderly patients. It can significantly reduce the volume of thyroid nodules and has slight influence on thyroid function.

Key words: aged, thyroid nodule, microwave ablation, thyroid function

CLC Number:

R 581.3

HU Cuining, TANG Wei, WU Dan, XU Ting, FAN Boqiang. Evaluation of efficacy and safety of microwave ablation in treatment of benign thyroid nodules in elderly patients[J]. Practical Geriatrics, 2024, 38(3): 251-254.

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Evaluation of efficacy and safety of microwave ablation in treatment of benign thyroid nodules in elderly patients

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