血清S100A12联合钙化特征评分对老年急性非ST段抬高型心肌梗死病人经皮冠状动脉介入治疗术后支架内再狭窄的预测价值

doi:10.3969/j.issn.1003-9198.2021.09.017

Abstract

Abstract: Objective To study the predictive value of serum S100A12 combined with calcification characteristic score for in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in the elderly patients with acute non-ST elevation myocardial infarction (NSTEMI). Methods A total of 220 elderly patients with NSTEMI who were treated by PCI in the Department of Cardiology of our hospital from January 2017 to October 2018 were selected. According to whether ISR occurred within one year after PCI, the patients were divided into ISR group and control group, with 34 cases and 186 cases respectively. The clinical data of the patients were collected, the characteristics of the plaque (including calcification, calcification length, calcification radian, calcification plaque type) were observed by intravascular ultrasound, and the calcification characteristic score was calculated. The level of serum S100A12 was measured by enzyme-linked immunosorbent assay. The risk factors for ISR after PCI were analyzed by univariate analysis and multivariate Logistic regression. The predictive value of calcification score, serum S100A12 and the combination for ISR after PCI was analyzed by receiver operating characteristic (ROC) curve. Results There were significant differences in calcification characteristics, calcification characteristics score and serum S100A12 level between the two groups (P<0.05). Multivariate Logistic regression analysis showed that high calcification characteristics score, high serum S100A12 level, long lesion length, calcification, long calcification length, large calcification radian and superficial calcification were the independent risk factors for ISR after PCI. ROC curve analysis showed that calcification characteristic score and serum S100A12 level had high value in predicting ISR after PCI, and the area under the cure (AUC) was 0.738 (0.626-0.870) and 0.736 (0.621-0.873), respectively. The combination of the two indexes showed higher value in predicting ISR after PCI, with an AUC of 0.835 (0.718-0.971). Conclusions Calcification characteristic score and serum S100A12 level are closely related to the occurrence of ISR after PCI, which can be used as independent influencing factors for ISR after PCI. The joint detection of the two indexes is more valuable than the single index in predicting ISR after PCI.

Key words: non-ST segment elevation myocardial infarction, percutaneous coronary intervention, restenosis, calcification, S100A12, aged

CLC Number:

R 541.6

ZHANG Zheng-nan. Predictive value of serum S100A12 combined with calcification characteristic score for in-stent restenosis after percutaneous coronary intervention in elderly patients with acute non-ST segment elevation myocardial infarction[J]. Practical Geriatrics, 2021, 35(9): 962-966.

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Predictive value of serum S100A12 combined with calcification characteristic score for in-stent restenosis after percutaneous coronary intervention in elderly patients with acute non-ST segment elevation myocardial infarction

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