中性粒细胞与淋巴细胞比值对老年稳定型心绞痛病人择期PCI围术期心肌损伤的预测价值

doi:10.3969/j.issn.1003-9198.2021.09.013

Abstract

Abstract: Objective To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and perioperative myocardial injury (PMI) of percutaneous coronary intervention(PCI) in the elderly patients with stable angina pectoris(SAP). Methods A total of 159 elderly patients with SAP hospitalized in our hospital for PCI were retrospectively selected from January 2016 to June 2018. The baseline data were collected and the levels of cardiac troponin T (cTnT), biochemistry parameters and the inflammatory factors before and after operation were detected. The best cut-off value of NLR was determined by receiver operating characteristic (ROC )curve. The patients were divided into high NLR group (NLR>2) and low NLR group (NLR≤2). The baseline data and the incidence rate of PMI between the two groups were observed and compared. Logistic regression analysis was used to analyze the risk factors of PMI. Results The best cut-off value of NLR was 2, with a area under the curve (AUC) of 0.76, with a sensitivity of 78.95%, with a specificity of 65.69%. There were significant differences in age, number of stents, total length of stents and incidence rate of PMI between the high NLR group and the low NLR group (P<0.05). The levels of Cystatin C, high-sensitivity C-reactive protein(hs-CRP), neutrophil count, NLR and platelet-to-lymphocyte ratio were significantly higher and the level of lymphocyte count was significantly lower in the high NLR group than that in the low NLR group(P<0.05). Multivariate Logistic regression analysis showed that smoking history(OR=2.699, 95%CI: 1.016-7.168) and NLR>2 (OR=4.332, 95%CI :1.641-11.433)were risk factors of PMI, while female(OR=0.219, 95%CI:0.073-0.656) and statins history (OR=0.210, 95%CI :0.045-0.982)were protective factors of PMI. Conclusions Preoperative high level of NLR is one of the risk factors for elderly patients with SAP, which can predict the occurrence of PMI in the elderly patients with SAP.

Key words: aged, stable angina pectoris, neutrophil-to-lymphocyte ratio, percutaneous coronary intervention, perioperative myocardial injury

CLC Number:

R 541.4

YIN Yun-Jie, JIANG Jian-dong, XU Liang, SUN Jun-xiang, ZHAO Xiang-hai, YANG Song, CHEN Yan-chun. Predictive value of the neutrophil-to-lymphocyte ratio for perioperative myocardial injury of percutaneous coronary intervention in elderly patients with stable angina pectoris[J]. Practical Geriatrics, 2021, 35(9): 943-947.

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Predictive value of the neutrophil-to-lymphocyte ratio for perioperative myocardial injury of percutaneous coronary intervention in elderly patients with stable angina pectoris

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