IL-16联合GRACE出院评分对老年非ST段抬高型急性冠状动脉综合征病人不良心脑血管事件的预测价值

doi:10.3969/j.issn.1003-9198.2021.09.012

Abstract

Abstract: Objective To explore the predictive value of interleukin-16 (IL-16) combined with global registry of acute coronary events (GRACE) discharge score for major adverse cardiovascular and cerebrovascular events (MACCE) in the elderly patients with non-ST elevation acute coronary syndrome (NSTE-ACS). Methods A total of 182 elderly NSTE-ACS patients who were treated in our hospital from January 2017 to August 2018 were selected. All the patients were followed up for 12 months. According to whether MACCE occurred, the patients were divided into MACCE group (n=38) and non-MACCE group (n=144). The general data and the levels of cardiac function indexes, IL-16 and the GRACE discharge score were observed and compared between the two groups. The risk factors of MACCE were analyzed by multivariate Logistic regression analysis. The predictive value of IL-6 and GRACE score for MACCE in the elderly patients with NSTE-ACS was analyzed by receiver operating characteristic (ROC) curve analysis. Results The age and the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), IL-16 and GRACE discharge score in MACCE group were significantly higher and the left ventricular ejection fraction (LVEF) was significantly lower than that in non-MACCE group (P<0.01). Multivariate Logistic regression analysis showed that LVEF was a protective factor, while age, NT-proBNP, IL-16 and GRACE discharge score were risk factors of MACCE in the elderly NSTE-ACS patients (P<0.05). ROC curve analysis showed that the area under the curve(AUC) of IL-16 was 0.727 (95%CI: 0.640-0.814), the AUC of GRACE discharge score was 0.781 (95%CI: 0.706-0.857), and the sensitivity and Yoden index of combined test were improved. Conclusions IL-16 combined with GRACE discharge score have a high predictive value for the occurrence of MACCE in the elderly NSTE-ACS patients.

Key words: non-ST segment elevation acute coronary syndrome, interleukin-16, global registry of acute coronary events discharge score, adverse cardiovascular and cerebrovascular events, predictive value

CLC Number:

R 541.4

JI Peng, SUN Wei, JIA Yu-qing. Predictive value of IL-16 combined with GRACE discharge score for adverse cardiovascular and cerebrovascular events in elderly patients with non-ST elevation acute coronary syndrome[J]. Practical Geriatrics, 2021, 35(9): 939-942.

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Predictive value of IL-16 combined with GRACE discharge score for adverse cardiovascular and cerebrovascular events in elderly patients with non-ST elevation acute coronary syndrome

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