Abstract: Objective To investigate the clinical effect of loop electrosurical excision procedure (LEEP) in the treatment of the elderly patients with high-grade cervical lesions and its influence on reversal rate. Methods A total of 143 elderly patients with high-grade cervical lesions from June 2017 to June 2019 were selected as subjects. They were divided into control group (n=70) and observation group (n=73) by random number table. The control group was treated with cold knife conization, and the observation group was treated with LEEP. The patients' surgical indicators were evaluated 3 days after the operation, and they were followed up for 6 months after the operation. The surgical indicators, reversion rate, incidence of complications and postoperative quality of life were compared between the two groups. Results The time of surgery, hospitalization and incision healing, intraoperative blood loss and operation cost in the observation group were less than those in the control group (P<0. 05). Six months after operation, there were no significant differences in the incidence of cervical canal adhesion, infection and vaginal bleeding between the two groups (P>0. 05). There was no significant difference in the reversion rate of the two groups in the first and sixth months after operation (P>0. 05). The scores of health, appetite, mental symptoms, physical sensation and sleep status in the observation group were higher than those in the control group (P<0. 05). Conclusions LEEP in the treatment of elderly patients with high cervical lesions has less surgical trauma, which can increase the reversion rate, reduce the incidence of postoperative complications, and improve the quality of life of the patients.

Key words: loop electrosurical excision procedure, cold knife conization, cervical lesions, reversion rate, curative effect, aged