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20 January 2021, Volume 35 Issue 1 Previous Issue    Next Issue

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Analysis of influencing factors of sarcopenia complicated with cognitive impairment in elderly inpatients ZHANG Lu-yin, MO Yong-zhen 2021, 35 (1):  10-14.  doi: 10.3969/j.issn.1003-9198.2021.01.004 Abstract ( 167 )   PDF (1043KB) ( 1147 )   Save Objective To obtain the prevalence and related influencing factors of sarcopenia complicated with cognitive impairment in the elderly inpatients. Methods A total of 445 elderly inpatients in our hospital from November 2018 to January 2020 were selected. All the subjects completed the measurement of bioelectrical impedance analysis, 6 m walk speed test, grip strength test and Mini Mental State Examination, and they were divided into four groups: no sarcopenia and no cognitive impairment group (n=222), sarcopenia group (n=121), cognitive impairment group (n=50), sarcopenia complicated with cognitive impairment group (n=52). Variance analysis and Logistic regression analysis were used to explore the influencing factors of sarcopenia complicated with cognitive impairment in the elderly inpatients. Results The detection rates of sarcopenia, cognitive impairment and the two combined were 38. 88% (173/445), 22. 92% (102/445) and 11. 69% (52/445), respectively. Univariate analysis showed that there were significant differences in age, body mass index (BMI), hypertension, diabetes, cerebrovascular disease, osteoporosis, education level, depression and nutrition status among the four groups (P<0. 05 or P<0. 01). Multivariate Logistic regression analysis showed that advanced age (OR=1. 259, 95%CI: 1. 138-1. 392, P<0. 001), depression (OR=10. 815, 95%CI: 2. 345-49. 885, P=0. 002), poor nutritional status (OR=4. 876, 95%CI: 1. 685-14. 108, P=0. 003), lower BMI (OR=0. 649, 95% CI:0. 549-0. 768, P<0. 001) were the independent influencing factors of sarcopenia complicated with cognitive impairment in the elderly inpatients. Conclusions In geriatrics ward, patients with advanced age, depression, poor nutritional status, lower BMI should be screened for sarcopenia and cognitive impairment in time. Intervention measures such as nutrition and exercise should be taken for these patients, so as to help them delay the body functional decline and improve the quality of life. References | Related Articles | Metrics

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Levels of serum oxidized low-density lipoprotein and myeloperoxidase in Tibetan and Han nationality people with mild cognitive impairment and Alzheimer's disease at high altitude JI Lei, ZHONG Xin, DU Can, LI Guo-feng, LI Hong-juan, ZHU Ai-qin 2021, 35 (1):  15-19.  doi: 10.3969/j.issn.1003-9198.2021.01.005 Abstract ( 151 )   PDF (1039KB) ( 1356 )   Save Objective To investigate the relationship between the levels of serum oxidized low-density lipoprotein (oxLDL) and myeloperoxidase (MPO) and the incidence of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in Tibetan and Han nationality people at high altitude. Methods The data of 60 patients with MCI, 60 patients with AD and 60 heathly normal control people (NC) of Tibetan and Han nationality living in Xining city of Qinghai Province were collected, with 30 cases in each ethnic subgroup. The cognitive function was assessed with Mini-Mental State Examination (MMSE). The levels of serum oxLDL and MPO were measured by enzyme linked immunosorbent assay. Spearman correlation analysis was performed to evaluate the relationship between the levels of oxLDL and MPO and the score of MMSE. Multivariate Logistic regression analysis was used to screen the risk factors of MCI and AD in Tibetan and Han nationality people. Results The level of oxLDL was significantly higher in Tibetan NC group than that in Han NC group (P<0. 05), and also significantly higher in Tibetan AD group than that in Han AD group (P<0. 01). The level of oxLDL in Tibetan NC group and Tibetan MCI group was significantly lower than that in Tibetan AD group (P<0. 01). The level of MPO was significantly higher in Han AD group than that in Han NC group (P<0. 05), and also significantly higher in Tibetan AD group than that in Tibetan MCI group (P<0. 01). There was a negative correlation between oxLDL level and MMSE score in Han nationality people (r=-0. 737, P<0. 001). The levels of oxLDL and MPO were both negatively related with MMSE score in Tibetan nationality people (r=-0. 794, P<0. 001; r=-0. 742, P<0. 001). Multivariate Logistic regression analysis showed that the increase of oxLDL was an independent risk factor for MCI and AD in the two nationalities, and the increase of MPO was an independent risk factor for MCI and AD in Tibetan nationality. Conclusions The cognitive function of Tibetan and Han nationality people at high altitude is related to serum oxLDL and MPO levels. It is important to monitoring the levels of oxLDL and MPO for screening the risk people. References | Related Articles | Metrics

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Effect of nutrition monitoring on quality of life in elderly patients with esophageal cancer after operation LI Dan-feng, MA Jing-jing, SU Dan, LI Hu 2021, 35 (1):  20-23.  doi: 10.3969/j.issn.1003-9198.2021.01.006 Abstract ( 148 )   PDF (1055KB) ( 1545 )   Save Objective To investigate the effect of nutrition monitoring on the nutritional status and quality of life in the elderly patients with esophageal cancer after operation. Methods A total of 96 elderly patients with esophageal cancer from January 2016 to May 2019 were randomly divided into two groups: the control group (48 cases) receiving routine enteral nutrition support after operation, and the observation group (48 cases) receiving nutrition support under the guidance of nutrition monitoring after operation. Both groups were intervened until discharge. The levels of nutritional indexes such as albumin (ALB), prealbumin (PA), hemoglobin (Hb), transferrin (TRF), arm muscle circumference (AMC) and the MOS item short from health survey (SF-36) scores before and after intervention were compared. Results After intervention, the time of hospitalization was significantly shorter and the incidence rate of complications was significantly lower in the observation group than that in the control group (P<0. 05); The levels of ALB, PA, Hb, TRF and AMC in the observation group were higher than those in the control group and those before intervention (P<0. 05), but there were no significant differences in the above indicators in the control group before and after intervention; The scores of SF-36 in both groups were higher than those before intervention (P<0. 05), especially in the observation group (P<0. 05). Conclusions Nutritional support intervention under the guidance of nutrition monitoring can improve the nutritional status and quality of life in the elderly patients with esophageal cancer after operation. References | Related Articles | Metrics

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Relationship between sleep disorders and frailty in elderly inpatients LAI Xiao-xing, BO Lin, ZHU Hong-wei, HUO Xiao-peng 2021, 35 (1):  24-27.  doi: 10.3969/j.issn.1003-9198.2021.01.007 Abstract ( 212 )   PDF (1014KB) ( 1445 )   Save Objective To explore the relationship between sleep disorders and frailty in the elderly inpatients. Methods A total of 501 hospitalized elderly patients were investigated and evaluated with general information questionnaire, Tilburg Frailty Scale and Pittsburgh Sleep Quality Index (PSQI). Results The incidence rate of sleep disorders was 56. 5%, and the incidence rate of frailty was 31. 3% in the elderly inpatients. There were significant differences in the scores of each dimension and total score of Tilburg Frailty Scale among the elderly inpatients with different sleep quality (P<0. 01). The scores of seven factors and total score of PSQI were positively correlated with the total score of Tilburg Frailty Scale (P＜0. 05). Conclusions The incidence rates of sleep disorders and frailty are high in the elderly inpatients. The prevention and intervention management of sleep disorders should be carried out from multiple dimensions, so as to improve the health level of elderly patients. References | Related Articles | Metrics

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Curative effect of loop electrosurical excision procedure in the treatment of elderly patients with cervical lesions WANG Wen-jie, LI Yong 2021, 35 (1):  28-31.  doi: 10.3969/j.issn.1003-9198.2021.01.008 Abstract ( 130 )   PDF (1007KB) ( 1279 )   Save Objective To investigate the clinical effect of loop electrosurical excision procedure (LEEP) in the treatment of the elderly patients with high-grade cervical lesions and its influence on reversal rate. Methods A total of 143 elderly patients with high-grade cervical lesions from June 2017 to June 2019 were selected as subjects. They were divided into control group (n=70) and observation group (n=73) by random number table. The control group was treated with cold knife conization, and the observation group was treated with LEEP. The patients' surgical indicators were evaluated 3 days after the operation, and they were followed up for 6 months after the operation. The surgical indicators, reversion rate, incidence of complications and postoperative quality of life were compared between the two groups. Results The time of surgery, hospitalization and incision healing, intraoperative blood loss and operation cost in the observation group were less than those in the control group (P<0. 05). Six months after operation, there were no significant differences in the incidence of cervical canal adhesion, infection and vaginal bleeding between the two groups (P>0. 05). There was no significant difference in the reversion rate of the two groups in the first and sixth months after operation (P>0. 05). The scores of health, appetite, mental symptoms, physical sensation and sleep status in the observation group were higher than those in the control group (P<0. 05). Conclusions LEEP in the treatment of elderly patients with high cervical lesions has less surgical trauma, which can increase the reversion rate, reduce the incidence of postoperative complications, and improve the quality of life of the patients. References | Related Articles | Metrics

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Effects of arterial and venous fistula blood flow on cardiac function and inflammatory reaction in elderly patients with hemodialysis LIU Jia-jun, LIAO Zhou-yi 2021, 35 (1):  32-35.  doi: 10.3969/j.issn.1003-9198.2021.01.009 Abstract ( 134 )   PDF (1025KB) ( 1068 )   Save Objective To explore the effect of arterial and venous fistula blood flow (AVFB) on the cardiac function and inflammatory response in the elderly patients receiving hemodialysis. Methods A total of 124 elderly patients who underwent hemodialysis with arteriovenous fistulas in our hospital from February 2017 to March 2018 were selected as the study subjects. According to the level of AVFB one month after arteriovenous fistula anastomosis, the patients were divided into high-flow group (>600 mL/min, n=38), medium-flow group (400-600 mL/min, n=45) and low-flow group (<400 mL/min, n=41). All the patients received one year maintenance hemodialysis treatment. The cardiac function, inflammatory response and hemodynamic indexes were detected, and the incidence rates of high-risk events and internal fistula dysfunction were recorded and compared among the three groups. Results Before dialysis, there were no significant differences in cardiac function, inflammatory response and hemodynamic indexes among the three groups (P>0. 05). After dialysis, with the increase of AVFB, the levels of ejection fraction, cardiac output, cardiac index, left ventricular end-systolic diameter, left ventricular end-diastolic diameter, interleukin-6, tumor necrosis factor-α, C-reactive protein, cardiac output, cardiac stroke volume and central blood volume were increased (P<0. 05), but the peripheral vascular resistance was decreased (P<0. 05). The incidence of high-risk events in the high-flow group was significantly higher than that in the low-flow group and medium-flow group (P<0. 05). The incidence rate of fistula dysfunction in the low-flow group was significantly higher than that in the high-flow group and medium-flow group (P<0. 05). Conclusions When the level of AVFB in the elderly patients receiving maintenance hemodialysis is controlled at 400-600 mL/min, the clinical effect is the best. References | Related Articles | Metrics

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Correlation analysis between serum lactate dehydrogenase and prognosis in elderly patients with newly diagnosed multiple myeloma CHEN Hao-yu, LU Xiu-pan, CHEN Li-juan, XU Ji 2021, 35 (1):  36-40.  doi: 10.3969/j.issn.1003-9198.2021.01.010 Abstract ( 164 )   PDF (1102KB) ( 1124 )   Save Objective To investigate the correlation between serum lactate dehydrogenase (LDH) and the clinical indicators in the elderly patients with newly diagnosed multiple myeloma (MM) and its prognostic significance. Methods The clinical data of 78 cases of newly diagnosed MM aged ≥65 years old in our hospital from July 2009 to January 2016 were analyzed retrospectively. The relationship between serum LDH level and prognosis was analyzed by Kaplan-Meier survival curve. The revised International Staging System (R-ISS) staging of 60 MM patients with complete data was carried out based on the patient's LDH level and fluorescence in situ hybridization test result, and the accuracy of prognostic judgment was compared with the International Staging System (ISS) staging. Results The median follow-up time for all the patients was 16. 5 months, and 11. 5% (9/78) of the patients showed elevated LDH levels at the first visit. The median survival time (OS) of the normal LDH group was 44. 0 months, compared with 14. 0 months of the elevated LDH group (P<0. 001); The median progression-free survival time (PFS) of the normal LDH group was 23. 0 months, compared with 12. 0 months of the elevated LDH group (P=0. 006). COX multivariate regression analysis showed that elevated LDH level was an independent poor prognostic factor for OS in the elderly MM patients (HR=5. 998, 95%CI: 2. 454-14. 664, P<0. 001). There were no significant differences in median OS and median PFS between stage Ⅱ and Ⅲ of ISS (44. 0 months vs 39. 0 months, P=0. 713; 26. 0 months vs 20. 0 months, P=0. 569), while there was significant difference in median OS (44. 0 months vs 15. 5 months, P<0. 001), and no significant difference in median PFS (21. 0 months vs 14. 0 months, P=0. 097) between stage Ⅱ and Ⅲ of R-ISS. Conclusions LDH level is an important indicator for judging the prognosis of the elderly MM patients. R-ISS staging based on LDH level is superior to ISS staging in predicting prognosis. References | Related Articles | Metrics

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Effects of compound polymyxin B ointment combined with traditional Chinese medicine sitz bath on wound healing and serum epidermal growth factor expression in elderly patients with perianal abscess after operation XU Yue-jun, GUO Zhi-wei, CHEN Yan, SHANG Wei, WANG Heng, HUANG Cheng-long, CHE Hao, QIN Hui 2021, 35 (1):  41-44.  doi: 10.3969/j.issn.1003-9198.2021.01.011 Abstract ( 206 )   PDF (1011KB) ( 1038 )   Save Objective To investigate the effects of compound polymyxin B ointment combined with traditional Chinese medicine sitz bath on wound healing and serum epidermal growth factor (EGF) expression in the elderly patients with perianal abscess after operation. Methods A total of 78 elderly patients with perianal abscess in our hospital were selected. The patients were randomly divided into the experimental group (n=40) and the control group (n=38) using single-blind random number table. All the patients took the hospital-made traditional Chinese medicine package sitz bath on the first day after surgery, 15-20 min/time, twice per day. After sitz bath, the patients in the experimental group were given compound polymyxin B ointment applications additionally. After 7 days of treatment, the wound healing of the two groups was observed. The quality of life was evaluated by pain visual analogue scores (VAS), life quality scale (SF-36) and Pittsburgh Sleep Quality Index (PSQI), and the level of serum EGF was detected by enzyme linked immunosorbent assay (ELISA). Results After 7 days of treatment, the wound healing rate of the experimental group was significantly higher than that of the control group (P<0. 05), and the wound edema rate was significantly reduced (P<0. 05); There was no significant difference in the incidence of anal fistula and wound bleeding (P>0. 05); The scores of VAS and PSQI in the experimental group were significantly lower (P<0. 01), and the SF-36 score and EGF level were significantly higher than those before treatment and those in the control group (P<0. 01). The wound healing rate of the experimental group and the control group was 40% and 26% respectively on the 10th day (P<0. 05). Conclusions Compound polymyxin B ointment combined with traditional Chinese medicine sitz bath has a good clinical effect on wound healing in the elderly patients with perianal abscess after surgery. It can relieve pain, improve quality of life and sleep status, and promote wound healing by increasing serum EGF level. References | Related Articles | Metrics

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Analysis of the risk and influencing factors of dementia in elderly patients with atrial fibrillation without stroke LIU Zhen, XU Xiao-hong 2021, 35 (1):  45-48.  doi: 10.3969/j.issn.1003-9198.2021.01.012 Abstract ( 135 )   PDF (1018KB) ( 1196 )   Save Objective To investigate the risk of dementia in the elderly patients with atrial fibrillation without stroke and to analyze the risk factors of dementia. Methods A total of 113 patients with atrial fibrillation without stroke admitted to the hospital from July 2014 to February 2017 were enrolled. The patients were divided into dementia group and control group based on the follow-up result. The clinical data and medication status of the two groups were analyzed, and the risk factors of dementia were analyzed by multivariate Logistic regression analysis. Results The median follow-up time of 113 patients was 41 (25-61) months. Six patients were lost to follow-up. Of the 107 patients with atrial fibrillation, 34 patients presented with dementia, with an incidence rate of 31. 77%. The age, and the proportion of persistent/permanent atrial fibrillation, hypertension and heart failure in the dementia group were significantly higher than those in the control group (all P<0. 05), while the administration rate of new oral anticoagulant was significantly lower (P<0. 05). Multivariate Logistic regression analysis showed that persistent/permanent atrial fibrillation (OR=33. 534), age (OR=1. 127), and hypertension (OR=10. 605) were independent risk factors for dementia (P<0. 05), and new oral anticoagulant (OR=0. 265) was a protective factor for dementia (P<0. 05). Conclusions The patients with atrial fibrillation without stroke should be highly alert to the occurrence of dementia, especially in the patients with persistent/permanent atrial fibrillation, but the new oral anticoagulant can effectively reduce the risk of dementia. References | Related Articles | Metrics

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Effect of sarcopenia on preoperative evaluation and postoperative complications in elderly patients with gastric cancer TAO Ping, PAN Chao 2021, 35 (1):  49-51.  doi: 10.3969/j.issn.1003-9198.2021.01.013 Abstract ( 158 )   PDF (1038KB) ( 1446 )   Save Objective To investigate the effect of sarcopenia on preoperative evaluation and postoperative complications in the elderly patients with gastric cancer. Methods The clinical data of 102 elderly patients with gastric cancer in Nanjing Hospital Affiliated to Nanjing Medical University from January 2008 to December 2019 were analyzed retrospectively. They were divided into sarcopenia group (n=49) and non-sarcopenia group (n=53). The preoperative nutritional status and hospital stay, postoperative complications, ICU occupancy rate and occupancy time, postoperative hospital stay, mortality were compared between the two groups. Results There were no significant differences in the level of preoperative hemoglobin, the incidence rates of postoperative abdominal infection and gastrointestinal fistula, the number of secondary operations and mortality between the two groups (P>0. 05). There were significant differences in the levels of preoperative albumin and prealbumin, the length of preoperative hospital stay and postoperative hospital stay, ICU occupancy rate and occupancy time, postoperative ventilation time, the incidence rates of postoperative pulmonary infection and pleural effusion between the two groups (P<0. 05). Conclusions Sarcopenia can be used as an objective index for preoperative evaluation in the elderly patients with gastric cancer. Preoperative sarcopenia will increase the incidence of postoperative complications and ICU occupancy rate in the elderly patients with gastric cancer. References | Related Articles | Metrics

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Correlation between platelet parameters and blood pressure in the elderly YU Shu-shu, WANG Guang-yu, QIAO Jin-ling, WANG Kun-wei 2021, 35 (1):  52-56.  doi: 10.3969/j.issn.1003-9198.2021.01.014 Abstract ( 162 )   PDF (1032KB) ( 1022 )   Save Objective To analyze the correlation between platelet parameters and blood pressure in the elderly. Methods The clinical data of 1023 elderly patients in Tianyou Hospital Affiliated to Tongji University from January 2016 to August 2019 were collected. According to the level of blood pressure, they were divided into three groups: normotension group (＜120/80 mmHg, n=215), prehypertension group [(120-139)／(80-89) mmHg,n=531] and hypertension group (≥140／90 mmHg,n=277). The correlation between platelet parameters and blood pressure was analyzed. Results The levels of mean platelet volume (MPV) and platelet distribution width (PDW) in hypertension group and prehypertension group were higher than those in normotension group (P<0. 05), but platelet count (PLT) and platelet thrombocytocrit (PCT) showed no significant difference among the three groups. Spearman correlation analysis showed that MPV and PDW were positively correlated with systolic blood pressure (SBP) (P<0. 01); PLT and PCT were not correlated with SBP (P＞0. 05); MPV, PDW, PLT and PCT were not correlated with diastolic blood pressure (DBP) (P＞0. 05). The multiple linear regression analysis showed that MPV was an independent factor of SBP (P<0. 01). All the elderly were divided into Q1-Q4 groups according MPV quartile division. Logistic regression analysis showed that the risk of hypertension in Q4 group was 1. 529 times of that in Q1 group (95％CI:1. 106-2. 319,P<0. 05) after adjusting for gender, age, height, body weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total cholesterol, triglyceride, low-density lipoprotein cholesterol, creatinine, alanine aminotransferase, fasting blood glucose, smoking and drinking. Conclusions Platelet parameters are closely related to blood pressure in the elderly, elevated MPV may be associated with the occurrence and development of hypertension. References | Related Articles | Metrics

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Analysis of the influencing factors of postoperative pulmonary infection in elderly patients with gastric cancer undergoing radical gastrectomy ZHU Zhi-xian, LI Jing-feng, TANG Jun, ZHANG Yan-hui, LIU Peng, ZHANG Jiao 2021, 35 (1):  57-60.  doi: 10.3969/j.issn.1003-9198.2021.01.015 Abstract ( 145 )   PDF (1012KB) ( 1092 )   Save Objective To explore the clinicopathological characteristics of the elderly patients with gastric cancer undergoing radical operation and the influencing factors of postoperative pulmonary infection. Methods The clinical data of 120 elderly patients with gastric cancer treated by radical operation in our hospital from January 2016 to June 2019 were retrospectively analyzed, and they were divided into study group (n=26) and control group (n=94) according to whether postoperative pulmonary infection occurred. The clinical and pathological data of the two groups were compared, and the independent risk factors of postoperative pulmonary infection in the elderly patients undergoing radical gastrectomy were analyzed by multivariate Logistic regression. Results Age(OR=3. 570, 95%CI:1. 150-9. 875), hypoalbuminemia(OR=3. 003, 95%CI:2. 851-4. 623), gastrointestinal decompression(OR=7. 538, 95%CI:3. 101-18. 203), perioperative blood transfusion(OR=6. 813, 95%CI:5. 323-8. 303), wound pain(OR=3. 417, 95%CI:1. 546-7. 537) and smoking history(OR=3. 662, 95%CI:1. 680-7. 992) were independent risk factors for postoperative pulmonary infection in the elderly patients undergoing radical gastrectomy. Conclusions The independent risk factors of pulmonary infection in elderly patients with gastric cancer after radical operation are age, hypoalbuminemia, gastrointestinal decompression, perioperative blood transfusion, wound pain and smoking history. It is important to strengthen the intervention measures against the above factors. References | Related Articles | Metrics

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Curative effect of super-selective prostatic artery embolization combined with transurethral prostatic resection for benign prostatic hyperplasia with volume>80 mL ZHU Lin-jie, WANG Wei, WANG Hai-dong, ZHAO Xin-jian 2021, 35 (1):  61-64.  doi: 10.3969/j.issn.1003-9198.2021.01.016 Abstract ( 141 )   PDF (1021KB) ( 1340 )   Save Objective To investigate the clinical effects and safety of super-selective prostatic artery embolization (PAE) combined with transurethral resection of the prostate (TURP) in the treatment of benign prostatic hyperplasia with volume>80 mL in the elderly patients. Methods The clinical data of 84 elderly patients with benign prostatic hyperplasia with volume>80 mL treated in our hospital from January 2016 to January 2019 were retrospectively analyzed. The patients were divided into control group (44 patients, undergoing TURP) and observation group (40 patients, undergoing super-selective PAE and TURP). The operation time, weight and speed of excised lesion, continuous bladder flushing time, catheter retention time, International Prostate Symptom Score (IPSS), quality of life (QOL) score, maximum urinary flow rate (Qmax) and residual urine volume (PVR), and postoperative complications were compared between the two groups. Results Compared with the control group, the operation time, continuous bladder flushing time, catheter retention time in the observation group were significantly less (P<0. 05), and the weight and speed of excised lesion were significantly more (P<0. 05). After operation, there were no significant differences in IPSS score, QOL score, Qmax and PVR between the two groups (P>0. 05), but the incidence rate of postoperative complication in observation group was significantly lower than that in control group (P<0. 05). Conclusions Compared with TURP alone, super-selective PAE + TURP in the treatment of benign prostatic hyperplasia patients with volume > 80 mL can efficiently shorten the operation time, increase the efficiency of tissue resection, speed up the rehabilitation process, relieve the clinical symptoms, improve the bladder function and quality of life, and reduce the postoperative complications risk. References | Related Articles | Metrics

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Efficacy of anlotinib in the treament of elderly patients with advanced non-small cell lung cancer with wild-type epidermal growth factor receptor XIE Qiang, ZHU Jin-xiu, ZANG Huan-ping, LIN Heng 2021, 35 (1):  65-68.  doi: 10.3969/j.issn.1003-9198.2021.01.017 Abstract ( 147 )   PDF (1360KB) ( 1466 )   Save Objective To evaluate the efficacy and safety of anlotinib in the treatment of elderly patients with advanced non-small cell lung cancer (NSCLC) with wild-type epidermal growth factor receptor (EGFR). Methods From June 2018 to March 2019, elderly patients with advanced NSCLC with wild-type EGFR were selected as the subjects. They underwent 2 weeks of treatment with anlotinib (12 mg/d) and 1 week of withdrawal, and 3 weeks was a course of treatment. The patients' objective response rate (ORR), disease control rate (DRR), progression free survival (PFS) and adverse reaction were recorded. Results A total of 26 patients aged 66-85 years, with a median age of 74. 5 years, were enrolled in this study. Among them, 21 cases were treated with first-line, 3 cases were treated with second-line and 2 cases were treated with third-line treatment. As of October 10, 2019, the patients' ORR was 11. 54% (3/26), DRR was 76. 92% (20/26), and the median PFS was 5. 1 months. The common adverse events were hypertension, hand-foot syndrome, fatigue, hemoptysis, thyroid dysfunction. No drug-related mortality occurred. Conclusions In the treatment of elderly patients with advanced NSCLC with wild-type EGFR, anlotinib could prolong the patients' PFS, improve ORR and DCR, and the adverse reactions are controllable. References | Related Articles | Metrics

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Correlation between frailty and sedentary behavior in community elderly LU Xia, LIU Yan-li, WANG Sha-sha, GUO Wei, YAN Xing-yu, HUANG Zhen 2021, 35 (1):  95-98.  doi: 10.3969/j.issn.1003-9198.2021.01.026 Abstract ( 136 )   PDF (1010KB) ( 1317 )   Save Objective To explore the correlation between frailty and sedentary behavior in the community elderly. Methods A total of 100 patients aged≥60 years in two communities of Jinan city were sampled by convenient sampling method, and the status of frailty and sedentary behaviors of the elderly in the community were assessed by Frailty Body Phenotype Scale, International Physical Activity Questionnaire (self-filled long questionnaire), and the correlation between frailty and sedentary behaviors of the elderly was analyzed. Results The incidence rate of frailty was 14%, and the incidence rate of pre-frailty was 41%. The average sedentary time of the elderly was 6. 59±2. 03 h/day. Compared with non-frailty group (5. 14±1. 56 h/day), the sedentary time of pre-frailty group (7. 34±1. 53 h/day) and frailty group (9. 05±0. 73 h/day) was significantly prolonged (P<0. 01). Pearson correlation analysis showed that Fried Frailty Phenotype Scale score was positive correlated with sedentary time (r=0. 706, P<0. 001). Logistic regression analysis showed that sedentary time was an independent influencing factor for frailty and 4 frailty phenotypes (low grip strength, self-fatigue, slow walking pace, low physical activity). Conclusions Sitting for a long time is an independent risk factor for frailty. Community geriatric nursing attendants could prevent the occurrence and dalay the development of frailty in the elderly by reducing sedentary behavior. References | Related Articles | Metrics

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The willingness to pay for care services and influencing factors among the in-home elderly JI Jia-lin, ZHI Meng-jia, HU Lin-lin 2021, 35 (1):  99-102.  doi: 10.3969/j.issn.1003-9198.2021.01.027 Abstract ( 145 )   PDF (1013KB) ( 1071 )   Save Objective To explore the willingness to pay and the level of payment for care services among the in-home elderly, and to analyze the influencing factors. Methods This cross-sectional study adopted a multistage stratified sampling method to survey the in-home elderly aged≥65 years in 16 communities and 8 villages of Anhui province. The influencing factors of willingness to pay were analyzed by Chi-square test and binary Logistic regression model. Results A total of 1371 participants were enrolled in this study. Among them, 229 (16. 7%) participants were willing to pay for care services. Multivariate Logistic regression analysis showed that education level, occupation before retired, number of children and type of endowment insurance were the independent factors influencing the willingness to pay for the care services. Conclusions The willingness to pay for care services among the in-home-bound elderly is greatly affected by social and economic status. When building a policy platform of home-based care services for the elderly, on the one hand, it is necessary to improve the elderly's awareness and acceptance of home-based care services; On the other hand, it is necessary to improve the elderly's ability to pay by providing low-income disability subsidies and establishing the long-term care insurance system. References | Related Articles | Metrics

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Investigation and analysis of the related factors of medical adhesive related skin injury in elderly inpatients LIU Ying, XIA Li-li, ZHU Jiao, XU Min-zheng 2021, 35 (1):  103-106.  doi: 10.3969/j.issn.1003-9198.2021.01.028 Abstract ( 147 )   PDF (1000KB) ( 1233 )   Save Objective To investigate the present situation and influencing factors of medical adhesive related skin injury (MARSI) in the elderly inpatients. Methods A total of 246 inpatients aged 60 years and over were investigated by using clinical data questionnaire and adhesive product questionnaire. Results There were 58 cases presenting with skin lesions, and the incidence of MARSI was 23. 58%. Multivariate Logistic regression analysis showed that age, nutritional status, comorbidities and skin problems were the independent influencing factors of MARSI in the elderly inpatients. Conclusions The incidence of MARSI in the elderly inpatients is closely related to age, nutritional status, comorbidities and skin. However, there is still a lack of relevant and complete nursing system. It is necessary to establish a standardized management process to reduce the incidence of MARSI. References | Related Articles | Metrics