血清sTREM-1联合降钙素原对老年胆道结石术后继发急性胆管炎的预测价值

doi:10.3969/j.issn.1003-9198.2024.07.016

Abstract

Abstract: Objective To investigate the predictive value of serum soluble myeloid cell trigger receptor-1 (sTREM-1) and procalcitonin (PCT) for secondary acute cholangitis (AC) in the elderly patients undergoing biliary calculi surgery. Methods A total of 145 elderly patients undergoing biliary calculus surgery from January 2019 to September 2022 were enrolled in this study, and the patients were divided into control group (without postoperative AC, n=56) and observation group (with postoperative AC, n=89). According to the degree of AC, the observation group was divided into three subgroups: mild group (n=37), moderate group (n=29) and severe group (n=23). The serum levels of white blood cells (WBC), C-reactive protein (CRP), PCT and sTREM-1 were detected and compared among the groups. Logistic regression was used to analyze the influencing factors of secondary AC and the severity. ROC curve was drawn to analyze the predictive efficiency of PCT and sTREM-1 levels for secondary AC in the elderly patients undergoing biliary caculi surgery. Results Compared with control group, the serum levels of WBC, CRP, PCT and sTREM-1 in observation group were significantly increased (P<0.01). Compared with mild group, the serum CRP, PCT and sTREM-1 levels in moderate group and severe group were significantly increased; Compared with moderate group, the serum levels of WBC and PCT in severe group were significantly increased (all P<0.05).Logistic regression analysis showed that the serum levels of CRP, PCT and sTREM-1 were the independent risk factors of postoperative AC and severe degree in the elderly patients (all P<0.05). ROC curve results showed that the combination detection of serum PCT and sTREM-1 showed higher predicting efficiency than single detection of them in predicting the incidence of postoperative AC and the severe degree (all P<0.05). Conclusions The serum PCT and sTREM-1 levels in the elderly patients with secondary AC after biliary calculi operation are significantly increased, and the combined detection of PCT and sTREM-1 has good predictive value for the incidence of postoperative AC.

Key words: soluble myeloid cell trigger receptor-1, procalcitonin, aged, biliary stones, acute cholangitis severity, predictive value

CLC Number:

R 657.4

SHI Yi, GAO Ji, WANG Peng, RUI Yiqi, BAI Jianfeng. Value of serum sTREM-1 combined with procalcitonin in predicting secondary acute cholangitis in elderly patients after biliary calculisurgery[J]. Practical Geriatrics, 2024, 38(7): 713-717.

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Value of serum sTREM-1 combined with procalcitonin in predicting secondary acute cholangitis in elderly patients after biliary calculisurgery

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