老年脑梗死后血管性痴呆病人血清AGEs、RAGE水平与病情严重程度的关系

doi:10.3969/j.issn.1003-9198.2023.08.023

Abstract

Abstract: Objective To investigate the relationship of serum advanced glycation end products (AGEs) and receptor of AGEs (RAGE) with dementia severity in the patients with vascular dementia after cerebral infarction. Methods A total of 96 elderly patients with vascular dementia after cerebral infarction (CI-VD group) and 84 elderly patients with simple cerebral infarction (CI group) who were admitted to the Central Theater Command General Hospital from January 2020 to June 2021 were enrolled. The serum levels of AGEs and RAGE were compared between the two groups. According to the severity of dementia, the CI-VD patients were divided into mild group (n=25), moderate group (n=39) and severe group (n=32), and the serum levels of AGEs and RAGE were compared among the three groups. Spearman correlation was used to analyze the correlation of serum AGEs and RAGE levels with disease severity. Multivariate Logistic regression analysis was used to analyze the influencing factors of the severity of dementia. Receiver operating characteristic (ROC) curve was used to analyze the value of serum AGEs and RAGE levels in predicting severe dementia in the elderly CI-VD patients. Results The serum levels of AGEs and RAGE in CI-VD group were higher than those in CI group (P<0.01), and significantly increased with the severity of dementia (P<0.05). Spearman correlation analysis showed that serum AGEs (r=0.446, P<0.001) and RAGE (r=0.469, P<0.001) were positively correlated with dementia severity. Multivariate Logistic regression analysis showed that education level, serum NSE, AGEs and RAGE levels were associated with the severity of dementia in the elderly CI-VD patients (P<0.05). ROC curve analysis showed that the optimal cut-off points of serum AGEs and RAGE levels for predicting the severity of dementia in elderly CI-VD patients were 33.07 μg/mL and 550.31 μg/mL, and the AUC of the combination of serum AGEs and RAGE levels was higher than that of AGEs or RAGE alone (P<0.05). Conclusions Serum levels of AGEs and RAGE are related to the severity of dementia in the elderly CI-VD patients, which can be used for predicting the severity of dementia.

Key words: aged, cerebral infarction, vascular dementia, advanced glycation end products, advanced glycation end products receptor

CLC Number:

R 749.13

LIU Li-juan, JIANG Man, CHENG Yong, MAO Gao-feng, FANG Huang. Relationship of serum levels of AGEs and RAGE with dementia severity in elderly patients with vascular dementia after cerebral infarction[J]. Practical Geriatrics, 2023, 37(8): 853-857.

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Relationship of serum levels of AGEs and RAGE with dementia severity in elderly patients with vascular dementia after cerebral infarction

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