Practical Geriatrics

Practical Geriatrics ›› 2022, Vol. 36 ›› Issue (2): 154-157.doi: 10.3969/j.issn.1003-9198.2022.02.012

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Effects of acetylcysteine aerosol inhalation combined with splenic polypeptide on the level of free cortisol and adrenocortictrophic hormone in elderly patients with severe lung infection

LIU Feng, TAN Yan, XU You-ling, HU Sha-sha   

  1. LIU Feng, XU You-ling, HU Sha-sha. Department of Respiratory and Critical Care, Pukou District Central Hospital, Nanjing 211800, China;
    TAN Yan. Department of Respiratory Medicine, Nanjing First Hospital, Nanjing 210006, China
  • Received:2021-03-23 Online:2022-02-20 Published:2022-02-28

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Abstract: Objective To analyze the effects of acetylcysteine atomization inhalation combined with spleen polypeptide on the serum levels of free cortisol(COR) and adrenocorticotrophic hormone (ACTH) in the elderly patients with severe pulmonary infection, and to analyze the efficacy. Methods A total of 86 elderly patients with severe pulmonary infection were selected from March 2018 to April 2019. All cases were randomly divided into the control group and the observation group according to the admission time. Patients in the control group were treated with acetylcysteine inhalation on the basis of routine treatment. Patients in the observation group received intravenous drip of spleen polypeptide on the basis of the control group. The clinical efficacy, the serum levels of free COR, ACTH and respiratory dynamics were compared between the two groups. Results The effective rate in the observation group was significantly higher than that in the control group(P<0.05). After treatment, and the levels of arterial partial pressure of oxygen(PaO2) and oxygenation index in the observation group were significantly higher, and the level of arterial partial pressure of carbon dioxide(PaCO2) was significantly lower than that in the control group(P<0.05). After treatment, the serum levels of free COR, ACTH in the observation group were significantly lower than those in the control group(P<0.05). The clinical symptoms of fever, cough, shortness of breath and moist rales of the lungs in the observation group were improved significantly earlier than those in the control group(P<0.05), and the mechanical ventilation time was significantly shortter than that of the control group(P<0.05). Conclusions Acetylcysteine atomization inhalation combined with spleen polypeptide can effectively improve the clinical symptoms, decrease the serum levels of free COR and ACTH in the elderly patients with severe pulmonary infection. It has a good clinical application prospect.

Key words: acetylcysteine, spleen polypeptide, aged, severe pulmonary infection, clinical effect

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