不同营养状态老年慢性心力衰竭病人血清IGF-1及IL-17的表达及其影响因素

doi:10.3969/j.issn.1003-9198.2022.01.019

Abstract

Abstract: Objective To study the expression of serum insulin like growth factor 1(IGF-1) and interleukin 17 (IL-17) and the influencing factors in the elderly patients with chronic heart failure (CHF) with different nutritional status. Methods A total of 200 elderly patients with CHF aged over 60 years old who were admitted to our hospital from December 2016 to December 2018 were selected as the subjects. According to the scores of the Mini Nutritional Assesment Scale (MNA), the patients were divided into malnutrition group (MNA<24) and normal nutrition group (MNA≥24). The levels of body mass index (BMI), upper arm circumference (AMC), calf circumference (CC), triceps skinfold thickness (TSF) were measured and compared between the two groups; The serum levels of total protein (TP), transferrin (TRF), prealbumin (PA), total cholesterol (TC), triacylglycerol (TG), hemoglobin (Hb), IGF-1 and IL-17 were detected and compared between the two groups. The linear regression model was established by stepwise regression to analyze the relationship between plasma IGF-1, LI-17 and nutritional status. Results The level of IGF-1 in the normal nutrition group was significantly higher, and the level of IL-17 was significantly lower than that in the malnutrition group (P<0.05); The levels of BMI, AMC, CC and TSF in the normal nutrition group were significantly higher than those in the malnutrition group (P<0.05). The levels of TP, TRF, PA, TC, TG and Hb in the normal nutrition group were significantly higher than those in the malnutrition group (P<0.05); The levels of BMI, AMC, CC, TSF, TP, PA, Hb were positively correlated with the level of IGF-1, and negatively correlated with the level of IL-17. They were the independent influencing factors of IGF-1 and IL-17. Conclusions In the elderly patients with CHF, the levels of IGF-1 and IL-17 are closely related to nutritional status. Malnutrition is a risk factor for the prognosis of the elderly patients with CHF.

Key words: chronic heart failure, aged, interleukin-17, insulin-like factor-1, mini nutritional assessment

CLC Number:

R 541

LI Wei, ZHAO Cui, WANG Guo-yu, JIANG Hai-sen. The expression and influencing factors of serum IGF-1 and IL-17 in elderly patients with chronic heart failure with different nutritional status[J]. Practical Geriatrics, 2022, 36(1): 73-76.

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The expression and influencing factors of serum IGF-1 and IL-17 in elderly patients with chronic heart failure with different nutritional status

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