早期个体化序贯营养支持对老年慢性阻塞性肺疾病急性加重病人预后的影响

doi:10.3969/j.issn.1003-9198.2022.01.016

Abstract

Abstract: Objective To explore the effect of early sequential nutrition support on inflammation reaction, immune function, lung function and nutritional status in the elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods In this prospective randomized controlled trial, 112 AECOPD patients diagnosed in our hospital from February 2019 to January 2020 were divided into sequential enteral nutrition support group(experiment group, n=56) and conventional nutrition support group(control group, n=56). The nutrition index, lung function index, inflammatory index and immune index were measured and compared before and after treatment in the two groups. The hospitalization time of the two groups were compared. Results After treatment, the score of Nutrition Risk Screeing (NR S2002) and the levels of BMI, serum albumin, serum prealbumin, and total protein in the experiment group were improved significantly than those before treatment and those in the control group(P<0.05). The forced expiratory volume in 1 s/forced vital capacity(FEV1/FVC),FEV1% predicted(FEV1% pred)in the experimental group, and white blood cell(WBC), neutrophil count(N), high-sensitivity C-reactive protein(hs-CRP), tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), immune function indexes (CD3⁺, CD4⁺, CD4⁺/CD8⁺, total lymphocyte count) were significantly improved than those in the control group (P<0.05). And the hospitalization time was significantly shorter than that of the control group (P<0.05). Conclusions For elderly patients with AECOPD, early individualized sequential nutritional support can help improve the prognosis and quality of life.

Key words: acute exacerbation of chronic obstructive pulmonary disease, sequential nutritional support, aged, inflammatory response, lung function, immune response

CLC Number:

R 563

WANG Peng, WANG Shuang, LI Wei, XIA Jia-jia, XIANG Qin. Effect of early sequential nutrition support on prognosis in elderly patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Practical Geriatrics, 2022, 36(1): 61-64.

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Effect of early sequential nutrition support on prognosis in elderly patients with acute exacerbation of chronic obstructive pulmonary disease

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