Abstract: Objective To study the risk factors of frailty in the elderly patients with coronary heart disease (CHD). Methods A total of 230 elderly patients with CHD admitted to our hospital from October 2018 to October 2020 were selected as the research objects. The hand grip strength, walking speed, five times sit up tests, 3 m stand up walk test and full foot distance test were evaluated in all patients. The general information of the patients was collected, including age, gender, body mass index(BMI), cardiac function classification, complications, depression and anxiety, and the laboratory biochemistry indexes were observed and analyzed. The patients were divided into the frail group and the non-frail group according to the evaluation of the Fried frailty criteria. The independent influencing factors of frailty were analyzed by multivariate Logistic regression. Results Of 230 cases of the elderly patients with CHD, there were 39 cases in prophase of frailty and 27 cases in phase of frailty, and they were enrolled in the frail group; And 164 cases(71.30%) withnot frailty were enrolled in the non-frail group. The age, 5 times sit up test and 3 m stand up walk test time of the frail group were significantly higher than those of the non-frail group, while the level of hemoglobin (Hb), hand grip strength and walking speed in the frail group were significantly lower than those in the non-frail group (P<0.05). The proportions of the patients with cardiac function grade Ⅱ, depression and unable to complete the full foot distance test of the frail group were significantly higher than those of the non-frail group (P<0.05). Multivariate Logistic regression analysis showed that age (OR=1.421,95%CI:1.217-1.659), cardiac function classification(OR=1.542,95%CI:1.086-2.189), depression(OR=1.482,95%CI:1.246-1.763),Hb(OR=1.427,95%CI:1.104-1.845), hand grip strength(OR=1.607,95%CI:1.214-2.127), walking speed(OR=1.352,95%CI:1.104-1.656), time of five times sit up test(OR=1.413,95%CI:1.201-1.662), time of 3 m standing walking (OR=1.541,95%CI:1.217-1.951), failure to complete the full foot distance test(OR=1.324,95%CI:1.075-1.631)were the independent risk factor for frailty in the elderly patients with CHD(P＜0.05). Conclusions Age, heart function grade, depression, Hb and muscle function test index are independent factors of frailty in the elderly patients with CHD.

Key words: coronary heart disease, aged, frailty, muscle function