Abstract: Objective To observe the effect of different concentrations of heparin sealing fluid on central venous catheter sealing in the elderly patients, and to provide theoretical basis for the use of the best concentration of sealing fluid. Methods A total of 495 elderly patients with central venous catheter were randomly divided into group A, B and C, with 165 cases in each group. In group A, B and C, heparin solution with concentration of 10. 00 U/mL, 31. 25 U/mL and 62. 50 U/mL was used for positive pressure sealing, respectively. The incidence of central venous catheter occlusion, platelet count(PLT) and coagulation function before and after catheter closure were observed and compared. Results There was no significant difference in the incidence rate of central venous catheter occlusion among the three groups (P>0. 05). There was no significant difference in the level of PLT among the three groups (P>0. 05). There were significant differences in prothrombin time (PT) and prothrombin activity (PA) before and after sealing in group C(P<0. 05). Conclusions 10 U/mL heparin sealing solution shows few effect on the elderly patients, and it can be used as the standard for sealing the central venous catheter in the elderly patients.

Key words: aged, central venous catheter, heparin sealing fluid