Abstract: Objective To investigate the effect of nerve monitoring combined with zero defect intervention mode in the elderly patients undergoing spinal surgery. Methods A total of 86 elderly patients undergoing spinal surgery from December 2019 to September 2020 in our hospital were divided into control group and observation group according to random number table, with 43 cases in each group. The control group was treated with zero defect intervention mode, and the observation group was treated with zero defect intervention mode combined with nerve monitoring. Before intervention and 7 days after intervention, the serum levels of interleukin-6 (IL-6), IL-8, tumor necrosis factor-α (TNF-α), cortisol (Cor), norepinephrine (NE) were detected and compared between the two groups. The general compliance questionnaire was used to investigate the patients’ satisfaction and compliance. The perioperative indexes, and the incidence rate of complications 7 days after intervention were compared between the two groups. Results There were no significant differences in the operation time and intraoperative blood loss between the two groups (P>0.05); The time of postoperative ambulation, anal exhaust, eating and hospital stay in the observation group was shorter than that in the control group (P<0.05). The levels of IL-6, IL-8, TNF-α, Cor and NE in both groups after intervention were higher than those before intervention (P<0.05), and the levels of the above indexes in the observation group were signicantly lower than those in the control group (P<0.05). The total incidence rate of complications in the observation group was lower than that in the control group (P<0.05). The satisfaction of nursing methods, nursing content and service attitude, and the compliance of rehabilitation exercise, regular review and medication in the observation group were higher than those in the control group (all P<0.05). Conclusions Nerve monitoring combined with zero defect intervention mode can reduce the surgical trauma, inflammatory stress reaction and postoperative complications in the elderly patients undergoing spinal surgery, which is helpful to increase the patients compliance and is worthy of popularization and application.

Key words: neural monitoring, zero defect intervention model, spinal surgery, inflammatory stress response, aged