Abstract: Objective To analyze the influencing factors of cardiac valve calcification(CVC) in the elderly patients receiving maintenance hemodialysis(MHD). Methods A total of 104 elderly MHD patients treated at the Blood Purification Center of Yangzhong People's Hospital from June to September 2022 were selected as the study subjects. Based on the presence of CVC, they were divided into CVC group(45 cases) and non-CVC group(59 cases). Baseline data, vascular endothelial function, coronary artery calcification scores, and cardiac structure and function were compared between the two groups. Logistic regression analysis was used to identify the risk factors for CVC in the elderly MHD patients. Results Age, total score of coronary artery calcification, left main coronary artery and right coronary artery calcification score, post-diastolic left ventricular wall thickness, post-diastolic ventricular septal thickness and left ventricular mass index in CVC group were significantly higher and brachial arterial flow-mediated dilatation(FMD) in CVC group was significantly lower than those in non-CVC group. Multivariate Logistic regression analysis showed that aging (OR=1.121,95%CI:1.025-1.227)and the level of FMD(OR=0.879,95%CI:0.791-0.978) were the related factors for CVC in the elderly MHD patients(All P<0.05). Conclusions Aging and the decline of FMD are risk factors for CVC in the elderly MHD patients. Detection of FMD may be helpful for early identification and early warning of CVC.

Key words: aged, maintenance hemodialysis, cardiac valve calcification