Abstract: Objective To explore the correlation between serum cholinesterase (ChE) and ventricular remodeling in the elderly patients with chronic heart failure. Methods A retrospective study was conducted in 118 elderly inpatients with chronic heart failure aged ≥70 years from Department of Geriatric Medicine of our hospital from March 2018 to July 2021. The levels of ChE and N-terminal brain natriuretic peptid (NT-proBNP), the baseline data of liver and kidney function, nutritional status and New York Heart Association (NYHA) cardiac function grading were collected. All patients were divided into the low-level group (<4000 U/L, n=50) and the high-level group (≥4000 U/L, n=68) based on the level of ChE. The left ventricular internal diameter (LVD), left atrium diameter (LAD), interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPEWT) and left ventricular ejection fraction (LVEF) were measured and compared between the two groups. Results Compared with the high-level group, the levels of hemoglobin (Hb), creatinine, blood urea nitrogen(BUN), total cholesterol (TC) and LVEF were lower, while the levels of LVD and NT-proBNP were higher, and the proportion of the patients with grade Ⅳ heart function was significantly increased in the low-level group(all P<0.05 or P<0.01). Pearson correlation analysis showed that ChE was positively correlated with LVEF (r=0.263, P=0.004), and negatively correlated with NT-proBNP and LVD(r=-0.490, P<0.001; r=-0.233, P=0.011).Spearman correlation analysis showed that ChE was negatively correlated with NYHA cardiac function grading (r=-0.621, P<0.001). Conclusions The level of ChE is negatively correlated with LVD, and positively correlated with LVEF in the elderly patients with heart failure.ChE might be helpful for clinical evaluation of ventricular remodeling in the elderly patients with heart failure.

Key words: cholinesterase, heart failure, ventricular remodeling, aged