Abstract: Objective To observe and evaluate the feasibility of general anesthesia without muscle relaxant through nasal tracheal intubation in the elderly patients receiving endoscopic retrograde cholangiopancreatography (ERCP). Methods A total of 180 elderly patients who underwent ERCP in endoscopy center of our hospital from April 2019 to April 2021 were randomly divided into tracheal intubation general anesthesia group using muscle relaxant (group S)and nasal tracheal intubation general anesthesia group without muscle relaxant(group N), with 90 cases in each group. At five time points as entering the room (T₀), anesthesia induction (T₁), endotracheal intubation(T₂),intubation of duodenal papilla or incision of oddis sphincter(T₃), post-extubation(T₄), the levels of heart rate(HR), mean arterial pressure (MAP), pulse oxygen saturation(SpO₂), bispectral index(BIS) value were recorded and the recovery time of spontaneous breathing, extubation time, postanesthesia care unit (PACU) retention time were detected, and the adverse events were recorded. Results In both groups, compared with T₀, the levels of HR,MAP and BIS were significantly decreased and the level of SpO₂ was significantly increased at T₁, T₂ and T₃, and the level of SpO₂ was decreased at T₄;Compared with T₁, the level of MAP was increased at T₃, and the levels of HR, MAP and BIS were increased, while the level of SpO₂ was decreased at T₄;Compared with T₂ and T₃, the levels of HR, MAP and BIS were increased and the level of SpO₂ was decreased at T₄(P<0.05).The level of HR at T₁and T₂, and the level of SpO₂ at T₄ showed significant differences between group N and group S(P<0.05).The time of respiratory recovery, extubation and PACU stay in group N were significantly shorter than those in group S,and the incidence rate of postoperative hypoxemia was significantly lower than that in group S. Conclusions In the elderly patients undergoing ERCP,general anesthesia without muscle relaxants can avoid muscle relaxant remnants, which can improve the recovery of the postoperative patients, and be helpful to the transport in endoscopy center.

Key words: muscle relaxant, endoscopic retrograde cholangiopancreatography, tracheal intubation, aged, general anesthesia