老年脓毒症病人RNA损伤与28 d死亡率的相关性研究

doi:10.3969/j.issn.1003-9198.2023.09.007

Abstract

Abstract: Objective To investigate the correlation between RNA damage and 28-d mortality in the elderly patients with sepsis. Methods The elderly patients with sepsis admitted to Department of Emergency were enrolled in this study. The data of age, gender, length of stay, mean arterial pressure, clinical laboratory indicators such as 8-oxoGuo concentration in urine after RNA oxidative damage, the Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score and Sequential Organ Failure Assessment(SOFA) score were recorded. The mortality rate of the patients was recorded after 28-d follow-up. The differences in the indicators between the survival group and the death group were analyzed, and the risk factors of 28-d mortality were analyze. Receiver operator characteristic curve analysis was used to evaluate the predictive value of the factors for 28-d mortality in the elderly patients with sepsis. Results 8-oxoGuo, APACHE Ⅱ score,SOFA score and dosage of norepinephrine were risk factors for 28-d mortality of the elderly patients with sepsis (OR=1.559, 2.065, 1.223, 11.602, respectively). 8-oxoguanosine had a high predictive value for 28-d mortality (AUC=0.847,Z=6.397,P<0.001), and the specificity and sensitivity was 87.5% and 70.8%, respectively. Conclusions Oxidative RNA damage is associated with 28-d mortality in the elderly patients with sepsis.

Key words: sepsis, aged, RNA damage, mortality

CLC Number:

R 632.2

GAO Rong, ZHANG Qi-dong, YANG Wen, ZHU Ying, YANG Run-hua. Correlation between RNA damage and 28-d mortality in elderly patients with sepsis[J]. Practical Geriatrics, 2023, 37(9): 890-892.

References

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Correlation between RNA damage and 28-d mortality in elderly patients with sepsis

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