基于Solumbra技术的取栓术治疗老年脑梗死病人的疗效及其神经损伤标志物水平变化

doi:10.3969/j.issn.1003-9198.2023.06.016

Abstract

Abstract: Objective To analyze the clinical efficacy of Solumbra technology in the treatment of the elderly patients with cerebral infarction and the effects on the serum nerve injury markers. Methods A total of 220 patients with cerebral infarction admitted to our hospital from January 2019 to January 2021 were randomly divided into the observation group and the control group, with 110 cases in each group. The observation group was treated with Solumbra technique, and the control group was treated with conventional stent thrombectomy. The clinical effect, adverse events, the scores of National Institute of Health Stroke Scale(NIHSS) and modified Rankin Scale (mRS), the levels of serum brain-derived neurotrophic factor (BDNF), neuron specific enolization (NSE) and nerve growth factor (NGF) were compared between the two groups. Results The number of thrombectomy and thrombectomy time were significantly lower, and the first-pass revascularization rate was significantly higher in the observation group than those in the control group (P<0.05). The thrombolysis in cerebral infarction (TICI) grade of the observation group was significantly better (P<0.05), and the incidence rate of secondary embolism was significantly lower in the observation group than those in the control group. The NIHSS score of the observation group was significantly lower than that of the control group 72 hours, 1 week and 30 days after operation (P<0.01). Thirty days after operation, the levels of BDNF and NGF were significantly higher, and the level of NSE was significantly lower in the observation group than those in the control group (P<0.01). Ninety days after operation, the good prognosis rates and mRS score of the observation group were significantly higher than those of the control group(P<0.05). Conclusions Solumbra thrombectomy can effectively improve the clinical efficacy and improve the neurological function and nerve injury markers.

Key words: stent thrombectomy, Solumbra, aged, cerebral infarction, secondary embolization, nerve injury markers

CLC Number:

R 743.33

BAI Jian-bing, WANG Yang, LI Zi-biao, XIANG Wen-jie. Effect of Solumbra technology in the treatment of elderly patients with cerebral infarction and the change of nerve injury markers[J]. Practical Geriatrics, 2023, 37(6): 603-606.

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Effect of Solumbra technology in the treatment of elderly patients with cerebral infarction and the change of nerve injury markers

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