Abstract: Objective To investigate the predictive value of anxiety on major adverse cardiovascular events (MACE) in the elderly patients with coronary heart disease(CHD) after percutaneous coronary intervention (PCI). Methods A total of 681 patients aged≥65 years undergoing PCI were enrolled in the study. The clinical data of the patients were collected. Hamilton Anxiety Scale (HAMA) was used to evaluate the anxiety of the patients. The incidence rate of MACE after discharge was recorded. MACE included cardiac death, nonfatal myocardial infarction, re-hospitalization for angina and heart failure. Results There were 96 patients dropping out and 585 patients completing the follow-up, finally. The mean follow-up time was 28.34±10.07 months. MACE occurred in 85 patients during the follow-up. There were significant differences in age, HAMA score and the proportion of smoking, hypertension, diabetes and CHD with different types between MACE group and non-MACE group(P<0.05 or P<0.01). Receiver operating characteristic (ROC) curve analysis showed that HAMA score was a relatively strong predictor of MACE in the elderly patients after PCI, and the area under the curve (AUC) was 0.736 (95%CI: 0.661-0.812, P<0.001). Multivariate Cox proportional risk regression model analysis showed that HAMA score, smoking, diabetes and family history of CHD were the independent risk factors for MACE in the elderly patients after PCI. Conclusions Anxiety is an independent risk factor for MACE in the elderly patients after PCI, and it has a certain predictive value for MACE in those patients.

Key words: anxiety, percutaneous coronary intervention, aged, major adverse cardiovascular events, coronary heard disease