芪葵颗粒联合度拉糖肽治疗老年临床期糖尿病肾病的近期疗效

doi:10.3969/j.issn.1003-9198.2023.04.007

Abstract

Abstract: Objective To observe the short-term effect of Qi-Kui granules combined with dulaglutide in the treatment of clinical stage of diabetic kidney disease (DKD)in the elderly. Methods A total of 80 elderly patients with clinical stage of DKD hospitalized in the Department of Endocrinology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine from November 2019 to June 2021 were enrolled and divided into experiment group and control group by random number table, with 40 cases in each group. The control group was subcutaneously injected with dulaglutide injection 1.5 mg once a week; The experiment group took Qi-Kui granules 10 g on the basis of the control group, 3 times daily. Both groups were treated for 12 weeks. The levels of fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), systolic blood pressure(SBP), diastolic blood pressure (DBP), total cholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol (HDL-C), serum creatinine(Scr), urinary albumin/creatinine ratio (UACR) and 24 hours urine protein(24hUTP) in both groups before and after treatment were compared. Results During the study, 5 cases fell off in the experiment group, and 4 cases fell off in the control group. After treatment, the levels of FPG, HbA1c, SBP, DBP, TC, TG and LDL-C in both groups were significantly lower than those before treatment (P<0.05 or P<0.01), but there were no statistical differences between the two groups (P>0.05); The levels of Scr, UACR and 24hUTP in both groups were significantly decreased after treatment (P<0.05 or P<0.01), especially in the experiment group (P<0.05). The total effective rate in the experiment group was higher than that in the control group (88.57% vs 55.56%, P<0.01). Conclusions Qi-Kui granules combined with dulaglutide can significantly reduce the levels of Scr and urinary protein in the elderly patients with clinical stage of DKD, and they show protective effect on renal.

Key words: aged, diabetic kidney disease, Qi-Kui granules, dulaglutide

CLC Number:

R 692.5

WANG Li-juan, FENG Fei, ZHOU Jing-bo, RUAN Yuan, ZHA Min, PU Qiang, YU Jiang-yi. Short-term effect of Qi-Kui granules combined with dulaglutide in the treatment of clinical stage of diabetic kidney disease in the elderly[J]. Practical Geriatrics, 2023, 37(4): 348-351.

References

[1] 中华医学会糖尿病分会微血管并发症学组. 糖尿病肾病防治专家共识[J]. 中华糖尿病杂志, 2014, 6(11):792-801.
[2] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J]. 中华糖尿病杂志, 2021, 13(4):320-321.
[3] 中华中医药学会肾病分会. 糖尿病肾病诊断、辨证分型及疗效评定标准(试行方案)[J]. 上海中医药杂志, 2007, 41(7):7-8.
[4] HOU J H, ZHU H X, ZHOU M L, et al. Changes in the spectrum of kidney diseases: an analysis of 40,759 biopsy-proven cases from 2003 to 2014 in China[J]. Kidney Dis: Basel, 2018, 4(1):10-19.
[5] ALICIC R Z, COX E J, NEUMILLER J J, et al. Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence[J]. Nat Rev Nephrol, 2021, 17(4):227-244.
[6] 郑晓辉,宋轶萱,史桂玲,等. 度拉糖肽治疗 2型糖尿病的临床研究进展[J]. 现代药物与临床, 2020, 35(1):184-188.
[7] GERSTEIN H C, COLHOUN H M, DAGENAIS G R, et al. Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial[J]. Lancet, 2019, 394(10193):131-138.
[8] CAI H D, SU S L, QIAN D W, et al. Renal protective effect and action mechanism of Huangkui capsule and its main five flavonoids[J]. J Ethnopharmacol, 2017, 206:152-159.
[9] WU X, HUANG Y, ZHANG Y, et al. Efficacy of tripterygium glycosides combined with ARB on diabetic nephropathy: a meta-analysis[J]. Biosci Rep, 2020, 40(11):BSR20202391.
[10] OUYANG S, LI W H, YU P, et al.Effect of Chinese herbal medicine for patients with benign thyroid nodules in adults: a protocol for systematic review and meta-analysis[J]. Medicine: Baltimore, 2021, 100(8):e24591.
[11] 谢绍锋,曹雯,胡咏新,等.芪葵颗粒对2型糖尿病肾病患者蛋白尿及炎症因子的影响[J]. 世界科学技术-中医药现代化, 2017, 19(1):149-152.

[1]	LI Jiang, QIU Yan, WANG Ting, WANG Dan, YU Yifan, PU Lingli, BU Ling. Correlation between preoperative SII/ALB and clinicopathologic features in elderly patients with lung adenocarcinoma [J]. Practical Geriatrics, 2024, 38(9): 893-896.
[2]	DAI Jing, CUI Yan. Correlation between glycosylated hemoglobin variability and cognitive dysfunction in elderly patients with type 2 diabetes mellitus [J]. Practical Geriatrics, 2024, 38(9): 931-935.
[3]	ZHENG Hong, QI Zhenbo, XU Peng, XU Jie, YU Xinyu, ZANG Yanan, ZHANG Zhaoyan. Effects of hypnotics on cognition function and daytime sleepiness in the elderly [J]. Practical Geriatrics, 2024, 38(9): 936-939.
[4]	ZHANG Xingxing, ZHANG Haiyang, HE Xiaojing, LU Xiang. Investigation on the relationship between different physical indexes and the risk of diabetes mellitus in the elderly [J]. Practical Geriatrics, 2024, 38(9): 940-943.
[5]	NI Hongyan, CHEN Yun, ZHANG Qibing, MA Yiming, XIE Chenglan. Effects of electroacupuncture on cognitive function and inflammatory factors in elderly patients undergoing lower limb orthopedic surgery during the perioperative period [J]. Practical Geriatrics, 2024, 38(9): 944-947.
[6]	LI Xiaomin, LI Xiaolin, LI Jie, WU Lei, HAO Ranran. Efficiency influencing factors of transanal double-balloon enteroscopy in elderly patients [J]. Practical Geriatrics, 2024, 38(9): 958-961.
[7]	CAI Huicui, CHEN Yan, WANG Yan, YE Jinjun, ZHU Yuying. Effects of diversified health education model with simple respiratory function exercise on cancer-related fatigue and compliance behavior in elderly patients with lung cancer receiving radiotherapy [J]. Practical Geriatrics, 2024, 38(9): 968-972.
[8]	WANG Xiaojiao, WANG Ning, CUI Hong, YE Tong, WANG Xiaoming. Influence of exercise rehabilitation in elderly patients with mild to moderate chronic heart failure [J]. Practical Geriatrics, 2024, 38(8): 775-778.
[9]	SHEN Chenjun, WANG Xiaoqing, TANG Degang, NING Ping. Correlation between standardized uric acid and renal function in elderly patients with chronic kidney disease aged 90 and over [J]. Practical Geriatrics, 2024, 38(8): 779-782.
[10]	HAO Shijie, ZOU Jianpeng, WEI Chen, LIU Qingjiang. Effect of comprehensive respiratory training on hypokinetic dysarthria in elderly patients with Parkinson’s disease [J]. Practical Geriatrics, 2024, 38(8): 783-787.
[11]	XIANG Chao, LUO Caidong. Analysis of the diagnostic value of T wave change of avL lead for the degree of coronary artery stenosis in elderly patients with coronary heart disease [J]. Practical Geriatrics, 2024, 38(8): 788-791.
[12]	LI Huiying, CAI Lili, ZHU Qiwei. Predictive value of plasma N-terminal pro-brain natriuretic peptide for prognosis in patients aged ≥80 years old with left ventricular hypertrophy [J]. Practical Geriatrics, 2024, 38(8): 797-801.
[13]	WANG Xinping, XIE Baimei, WEI Guo, YE Xiaoli, ZHAO Yayun, TAN Xiaotian. Expression levels and clinical significance of serum S100A9 and sCD163 in elderly patients with idiopathic interstitial pneumonia [J]. Practical Geriatrics, 2024, 38(8): 802-807.
[14]	LIU Meijuan, WANG Ning, WANG Dong, LU Fangzhou, LIU Juan. Effect of low-dose lidocaine combined with propofol on motor evoked potential in elderly patients undergoing intracranial tumor resection [J]. Practical Geriatrics, 2024, 38(8): 808-811.
[15]	LI Jingbing, WANG Huijun, WANG Shaoying, ZHAO Can, WANG Lidi, CAO Yujiao. Impacts of pentoxifylline combined with lipoic acid intervention on physical function and quality of life in elderly patients with frailty syndrome [J]. Practical Geriatrics, 2024, 38(8): 812-815.

Short-term effect of Qi-Kui granules combined with dulaglutide in the treatment of clinical stage of diabetic kidney disease in the elderly

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 10