Abstract: Objective To investigate the predictive value of creatine kinase isoenzyme (CK-MB), B-type natriuretic peptide (BNP) and fibrinogen to albumin ratio (FAR) on readmission rate in the elderly patients with chronic heart failure (CHF). Methods A total of 132 CHF patients admitted to our hospital from March 2018 to October 2020 were enrolled. According to the New York Heart Association (NYHA)cardiac function classification, there were 55 cases of grade Ⅱ, 41 cases of grade Ⅲ and 36 cases of grade Ⅳ. All the patients were followed up for 1 year and were divided into the readmission group (45 cases) and the non-readmission group (87 cases) according to whether they were readmitted. The serum levels of C-reactive protein (CRP), procalcitonin (PCT), BNP, CK-MB and FAR in the two groups were detected and compared. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of CRP, PCT, CK-MB, BNP, and FAR for readmission in the elderly patients with CHF. Results The levels of CRP, PCT, BNP, CK-MB and FAR in grade Ⅱ, grade Ⅲ and grade Ⅳ group were significantly increased in turn (P<0.05).Compared with the non-readmission group, the levels of CRP, PCT, BNP, CK-MB and FAR were significantly higher in the readmission group (P<0.05).The ROC curve showed that the area under the curve (AUC) of CRP, PCT, BNP, CK-MB, and FAR for predicting readmission of CHF patients was 0.790, 0.785, 0.804, 0.841, and 0.869, respectively. The AUC of the combination of BNP,CK-MB and FAR to predict the readmission of CHF patients was 0.884, and the sensitivity and specificity was 82.20% and 88.50%, respectively. Conclusions The serum levels of CK-MB, BNP, and FAR are high in CHF readmission patients, and the combination detection of the three indexes shows significant clinical value in predicting CHF readmission.

Key words: aged, chronic heart failure, creatine kinase isoenzyme, B-type natriuretic peptide, fibrinogen to albumin ratio