Abstract: Objective To investigate the risk factors of bloodstream infections(BSI) in the aged critically ill patients in Intensive Care Unit(ICU). Methods The study retrospectively analyzed the clinical data of 120 cases of aged critically ill patients admitted to Nanjing Hospital of Chinese Medicine from January 2017 to December 2020. According to the results of blood culture, the cases were divided into BSI group(n=64) and non-BSI group(n=56). The differences in gender, age, APACHEⅡscore, Nutric score, comorbidities, the length of ICU stay, invasive operations between the two groups were analyzed. Then multivariate Logistic regression analysis was performed to investigate the risk factors of BSI. Results Univariate analysis showed that the patients in BSI group had higher nutritional risk than non-BSI group. The incidence rates of tumor, diabetes, urinary tract infection, gastrointestinal dysfunction and antimicrobial exposure in BSI group were higher than those in non-BSI group(P < 0.05). Multivariate Logistic regression analysis showed that malignant tumors (OR=2.476, 95%CI: 1.032-5.941), gastrointestinal dysfunction (OR=3.410, 95% CI: 1.366-8.514), history of antimicrobial exposure (OR=3.705, 95% CI: 1.516-9.057) and high nutritional risk (OR=7.005, 95% CI: 2.588-18.957, P< 0.01) were the independent risk factors of BSI in the aged critically ill patients. Conclusions The aged critically ill patients with high malnutrition risk, malignant tumor, gastrointestinal dysfunction and history of antimicrobial exposure are prone to suffer from BSI.

Key words: bloodstream infections, gastrointestinal dysfunction, risk factors, aged