Abstract: Objective To investigate the expression of human epidermal growth factor receptor 2 (HER2), cysteine-rich 61 (Cyr61) and insulin-like growth factor binding protein 3 (IGFBP3) and the value in predicting the prognosis of the elderly patients with endometrial cancer. Methods From January 2015 to January 2017, 124 elderly patients with endometrial cancer admitted to Department of Obstetrics and Gynecology of our hospital were selected as endometrial cancer group, 120 elderly patients with benign uterine lesions selected as benign lesion group, and 120 elderly women undergoing physical examination in the same period selected as the control group. The expression of HER2, Cyr61 and IGFBP3 among the three groups were detected by immunohistology. The patients with endometrial cancer were followed up for 5 years. Results In the control group, benign lesion group and endometrial cancer group, the positive expression rate of HER2 was 7.5%, 18.3% and 69.4%, respectively; The positive expression rate of Cyr61 was 10.0%, 12.5% and 76.6%, respectively; The positive expression rate of IGFBP3 was 59.2%, 51.7% and 29.0%, respectively, with significant differences among the three groups(P＜0.01). The positive expression of HER2 was correlated with age, pathological stage, tissue differentiation, lymph node metastasis, depth of muscle layer invasion and pathological type (all P<0.05). The positive expression of Cyr61 was correlated with pathological stage, lymph node metastasis, depth of muscle layer invasion and pathological type (all P<0.05). The positive expression of IGFBP3 was correlated with lymph node metastasis, depth of muscule layer invasion and pathological type (all P<0.05). The 5-year survival rates of the patients with negative expression of HER2 and Cyr61 were higher than those in the patients with positive expression, and the 5-year survival rate of the patients with positive expression of IGFBP3 was higher than that in the paitents with negative expression. Conclusions The abnormal expression of HER2, Cyr61 and IGFBP3 in the elderly patients with endometrial cancer is closely related to lymph node metastasis, depth of muscle layer invasion, pathological type and the prognosis.

Key words: human epidermal growth factor receptor 2, cysteine-rich 61, insulin-like growth factor binding protein, endometrial cancer, prognosis, aged