老年帕金森病病人呼吸暂停低通气与认知损伤的相关性

doi:10.3969/j.issn.1003-9198.2022.03.007

Abstract

Abstract: Objective To explore the relationship between the cognitive impairment and sleep apnea hypopnea syndrome in the elderly patients with Parkinson’s disease(PD). Methods This study evaluated 425 elderly patients with PD using Unified PD Rating Scale (UPDRS) part Ⅲ, Hoehn and Yahr (H&Y) staging, Non-Motor Symptoms Questionnaire (NMS-Quest), PD Sleep Scale (PDSS), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD) and Montreal Cognitive Assessment (MoCA). At the same time, polysomnography (PSG) was used to assess the sleep conditions. The relationship between cognitive impairment and sleep apnea hypopnea was analyzed. Results Cognitive damage was found in 182 PD patients(42.8%) with higher scores of HAMA, NMS, HAMD and anxiety/somatosis, body quality change and the awareness damage, with lower score of PDSS (P<0.05). The patients with cognitive injury presented with lower sleep efficiency, delayed sleep latency and average oxygen, with higher rate of NREM sleep stage 1 time (N1 time) and higher level of sleep-related apnea hypopnea index (AHI) and micro-wake index (all P<0.05). Logistic regression analysis indicated that AHI index was a risk factor of cognitive injury, while higher PDSS score, sleep efficiency, and average blood oxygen saturation in sleep were protective factors (P<0.05). Conclusions The cognitive damage in the elderly PD patients is closely related to sleep apnea hypopnea.

Key words: Parkinson’s disease, sleep apnea hypopnea, cognitive impairment, aged

CLC Number:

R 742

ZHU Jun, ZHANG Li, XU Shu-lan, YAN Jun, ZHANG Juan, ZHU Yin, CHEN Shu. Study on sleep apnea hypopnea and cognitive injury in elderly patients with Parkinson’s disease[J]. Practical Geriatrics, 2022, 36(3): 240-243.

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Study on sleep apnea hypopnea and cognitive injury in elderly patients with Parkinson’s disease

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