调强放疗联合小剂量阿帕替尼治疗老年食管癌的疗效观察

doi:10.3969/j.issn.1003-9198.2022.02.010

Abstract

Abstract: Objective To compare the efficacy and adverse effects of intensity modulated radiotherapy combined with apatinib and intensity modulated radiotherapy alone in the elderly patients with esophageal cancer. Methods A total of 60 elderly patients with esophageal cancer were retrospectively collected and divided into the radiotherapy group and the radiotherapy combined with apatinib group (combination group). Both groups received intensity modulated radiotherapy, and the combination group received apatinib tablets 250 mg/d in addition during and after radiotherapy. Results All the patients completed radiotherapy as planned, and the overall efficacy rate of the combined group and the radiotherapy group was 76.67%(23/30) and 70.00%(21/30), respectively, with no significant difference(P>0.05). The proportion of cases with depth of response≥50% in the combination group was 73.34%(22/30), compared with 46.67%(14/30) in the radiotherapy group(P=0.035). The median progression-free survival time(PFS) in the combination group was 16 months, compared with 11 months in the radiotherapy group(P=0.042). The 2-year survival rate of the combination group and the radiotherapy group was 49.00% and 40.00% respectively, and there was no significant difference(P=0.064). The incidence rate of radiation esophagitis was not significantly different between the two groups (P>0.05); Additionally, in the combination group, 23.33%(7/30) showed proteinuria, 20.00%(6/30) showed hypertension, and 10.00% (3/30) showed hand-foot syndrome, all of which were grade I-II adverse effects. Conclusions Low-dose apatinib combined with radiotherapy can in crease the depth of tumor response and PFS, without increasing the risk of radiation esophagitis, and the other side effects can be tolerated.

Key words: aged, esophageal cancer, apatinib, intensity modulated radiotherapy

CLC Number:

R 735.1

WANG Yu-fang, LIU Mei-rong, LI Ming-jun. Curative effect of intensity modulated radiotherapy combined with low-dose apatinib in the treatment of elderly patients with esohageal cancer[J]. Practical Geriatrics, 2022, 36(2): 146-149.

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Curative effect of intensity modulated radiotherapy combined with low-dose apatinib in the treatment of elderly patients with esohageal cancer

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