老年住院病人血清胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3与衰弱的相关性研究

doi:10.3969/j.issn.1003-9198.2022.01.015

Abstract

Abstract: Objective To investigate the relationship between serum insulin-like growth factor-1(IGF-1), insulin-like growth factor binding protein-3(IGFBP-3) and frailty in the elderly inpatients. Methods A total of 195 elderly inpatients aged 65 years old and over in the geriatric department were recruited from January 2018 to June 2019. Frailty phenotype assessment and comprehensive geriatric assessment were conducted. The serum levels of IGF-1 and IGFBP-3 were detected by enzyme-linked immunosorbent assay (ELISA). The correlations between IGF-1, IGFBP-3 levels and frailty were analyzed by ordinal multi-factorial Logistic regression. Results Serum levels of IGF-1 and IGFBP-3 in the elderly inpatients with frailty were significantly lower than those in non frailty and pre-frailty groups (P＜0.05). Ordered multi-variate Logistic regression analysis showed that the serum levels of IGF-1(OR=0.943, 95%CI:0.894-0.994,P＜0.05)and IGFBP-3(OR=0.397, 95%CI:0.259-0.607, P＜0.001)were significantly correlated with frailty. Conclusions Serum levels of IGF-1 and IGFBP-3 are significantly correlated with frailty in the aged inpatients, and might be used as a predictor for frailty in the aged.

Key words: insulin-like growth factor-1, insulin-like growth factor binding protein-3, frailty, aged

CLC Number:

R 592

HUANG Bao-feng, CHEN Wen-bo, JIANG Ke-wei, JIANG Xin. Association between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and frailty in elderly inpatients[J]. Practical Geriatrics, 2022, 36(1): 57-60.

References

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Association between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and frailty in elderly inpatients

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