Abstract: Objective To investigate the application of urinary microalbumin/creatinine (ACR) in screening chronic kidney disease (CKD) in the elderly. Methods A total of 1029 elderly who underwent ACR examination in the health management center of the Second Affiliated Hospital of Nanjing Medical University from March 2016 to June 2019 were randomly selected and divided into two groups: ACR+ group with ACR≥30 mg/g and ACR- group with ACR<30 mg/g. The general clinical characteristics and laboratory parameters of the two groups were compared. The clinical data were stratified and assigned into Logistic regression equation to analyze the influencing factors of ACR+. Results The detection rate of ACR+ was 21. 67% in the elderly undergoing physical examination. The levels of body mass index (BMI), fasting plasma glucose (FPG), systolic blood pressure, blood uric acid and triglyceride (TG) of ACR+ patients were significantly higher than those of ACR- patients. Most of the subjects were in the stage before CKD 3 stage, and ACR+ was positively correlated with CKD stage. Multivariate Logistic regression analysis showed that age (OR=1. 761, 95% CI: 1. 406-2. 205), BMI (OR=1. 479, 95% CI: 1. 237-1. 767), hypertension (OR=1. 228, 95% CI: 1. 228-1. 872), FPG blood glucose (OR=1. 913, 95% CI: 1. 544-2. 371) were positively correlated with ACR+. Conclusions High blood glucose, hypertension and high BMI are independent risk factors of proteinuria in the elderly. ACR detection is helpful for early detection of CKD in these people.

Key words: urinary albumin creatinine ratio, aged, chronic kidney disease