纤维蛋白原/白蛋白比值预测老年急性缺血性卒中血管内治疗术后预后不良的价值

doi:10.3969/j.issn.1003-9198.2021.03.008

Abstract

Abstract: Objective To investigate the predicting value of the ratio of fibrinogen to albumin (FAR) for the adverse prognosis in the elderly patients with acute ischemic stroke receiving endovascular treatment. Methods The clinical data of the elderly patients who received endovascular treatment of anterior circulation in Nanjing First Hospital were collected, prospectively, from May 2015 to November 2018. The outcome of the patients was evaluated 90 days after treatment, and they were divided into good prognosis group and poor prognosis group. The baseline data were compared between the two groups. The influencing factors of prognosis were investigated by the multivariate Logistic regression. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of FAR to the poor prognosis after 90 days. Results The age, history of stroke, baseline NIHSS score, ASITN/SIR collateral circulation grade 0-2, symptomatic intracranial hemorrhage, fasting blood glucose and FAR in the poor prognosis group were significantly higher than those in the good prognosis group, and the level of homocysteine in the poor prognosis group was lower (P<0. 05). Multivariate Logistic regression showed that FAR (OR=25. 048, 95%CI:8. 938-44. 733) was an independent predictor of poor prognosis after 90 days, after adjusting for the confounding factors including age, history of stroke, baseline NIHSS score, ASITN/SIR collateral circulation grade 0-2, symptomatic intracranial hemorrhage, fasting blood glucose and homocysteine. The area under the ROC curve of the FAR for predicting poor prognosis after 90 days was 0. 711 (95% CI: 0. 645-0. 772, P<0. 001). The sensitivity and specificity of predicting the poor prognosis were 60. 23% and 84. 17%, and the optimal cut-off value of FAR was 0. 0868. Conclusions The increasing FAR level may be able to predict poor outcome at 90 days in the elderly patients with acute ischemic stroke undergoing the endovascular treatment of anterior circulation.

Key words: brain ischemia, endovascular treatment, prognosis, fibrinogen to albumin ratio, risk factors, aged

CLC Number:

R 743.33

ZHANG Zhong-hua, HUANG Qing, LIU Chun-mei, SHI Bao-zhu. Correlation between fibrinogen to albumin ratio and poor prognosis 90 days after endovascular treatment in elderly patients with acute ischemic stroke[J]. Practical Geriatrics, 2021, 35(3): 241-245.

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Correlation between fibrinogen to albumin ratio and poor prognosis 90 days after endovascular treatment in elderly patients with acute ischemic stroke

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