血清sirtuin1、sirtuin6联合预测老年冠心病病人合并衰弱的效能

doi:10.3969/j.issn.1003-9198.2025.08.013

摘要/Abstract

摘要： 目的探讨血清沉默信息调节蛋白(sirtuin)1、sirtuin6联合预测老年CHD病人合并衰弱的效能。方法选取2022年5月至2024年7月广元市第一人民医院收治的老年CHD病人235例,根据是否合并衰弱分为衰弱组(81例)和非衰弱组(154例),收集病人的一般临床资料,采用酶联免疫吸附法检测血清sirtuin1、sirtuin6水平。通过单因素分析与多因素非条件logistic回归分析老年CHD病人合并衰弱的影响因素,采用ROC曲线分析血清sirtuin1、sirtuin6水平对衰弱的预测价值。结果 235例老年CHD病人衰弱发生率为34.47%(81/235)。2组间年龄、NYHA心功能分级、营养不良、近1年跌倒史比例,白蛋白、血红蛋白水平差异有统计学意义(P＜0.05),衰弱组血清sirtuin1、sirtuin6水平低于非衰弱组(P＜0.05)。多因素logistic回归分析显示,年龄大、NYHA心功能分级Ⅲ级、营养不良,低sirtuin1、sirtuin6水平为老年CHD病人合并衰弱的独立危险因素(P＜0.05)。血清sirtuin1、sirtuin6水平联合预测老年CHD病人合并衰弱的ROC曲线下面积为0.890,大于sirtuin1、sirtuin6单独的预测效能(0.811、0.800,均P＜0.05)。结论血清sirtuin1、sirtuin6水平降低是老年CHD病人并发衰弱的危险因素,且二者联合预测老年CHD病人合并衰弱的效能较高。

关键词: 老年人, 冠心病, 衰弱, 沉默信息调节蛋白1, 沉默信息调节蛋白6

Abstract: Objective To explore the efficacy of serum silent information regulator protein (sirtuin)1 combined with sirtuin6 in predicting frailty in the elderly patients with coronary heart disease (CHD). Methods A total of 235 elderly CHD patients admitted to Guangyuan First People’s Hospital from May 2022 to July 2024 were enrolled. All patients were divided into the frailty group (81 cases) and the non-frailty group (154 cases). The general clinical data were collected and the serum levels of sirtuin1 and sirtuin6 were measured by enzyme-linked immunosorbent assay. The influencing factors of frailty in the elderly CHD patients were analyzed by univariate analysis and multivariate unconditional logistic regression. The predictive value of serum sirtuin1 and sirtuin6 for frailty were analyzed by receiver operating characteristic(ROC) curve. Results Among the 235 elderly CHD patients, the incidence rate of frailty was 34.47% (81/235). Age, New York Heart Association (NYHA) cardiac function classification, malnutrition, history of falls within the past year, the levels of albumin and hemoglobin showed statistically significant differences between the two groups (all P<0.05). Compared to the non-frailty group, the serum sirtuin1 and sirtuin6 levels were lower in the frailty group (P<0.05). Multivariate logistic regression analysis showed that age, NYHA functional class Ⅲ, malnutrition, decreased levels of sirtuin1 and sirtuin6 were independent risk factors for frailty in the elderly CHD patients (P<0.05). The area under ROC curve (AUC) of sirtuin1 combined with sirtuin6 in predicting frailty was 0.890, which was significantly higher than that of sirtuin1 (0.811) and sirtuin6 (0.800) alone (all P<0.05). Conclusions Decreased serum sirtuin1 and sirtuin6 levels are risk factors for frailty in elderly patients with CHD, and the combination of serum sirtuin1 and sirtuin6 has high predictive efficiency.

Key words: aged, coronary heart disease, frailty, silent information regulator protein 1, silent information regulator protein 6

中图分类号:

R541.4
R592

韩丹, 刘盼, 王晓英, 赵媛媛, 杜长洪. 血清sirtuin1、sirtuin6联合预测老年冠心病病人合并衰弱的效能[J]. 实用老年医学, 2025, 39(8): 818-821.

HAN Dan, LIU Pan, WANG Xiaoying, ZHAO Yuanyuan, DU Changhong. Efficacy of serum sirtuin1 combined with sirtuin6 in predicting frailty in elderly patients with coronary heart disease[J]. Practical Geriatrics, 2025, 39(8): 818-821.

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