炎症与衰弱的关系研究进展

doi:10.3969/j.issn.1003-9198.2025.07.001

摘要/Abstract

摘要： 慢性炎症反应是加速衰老和促进衰弱的核心机制之一,其通过多系统交互作用形成炎症-衰弱恶性循环。慢性炎症可能是细胞衰老和线粒体功能障碍等非感染性诱因的反应,它会抑制生长因子表达并且增加分解代谢,进而导致肌肉减少和衰弱。而衰弱不仅是慢性炎症的结果,还可能通过免疫失调、代谢紊乱、线粒体功能障碍及肠道菌群失衡等机制反向加剧全身性炎症反应。本文通过综述衰弱与炎症的相互影响及其潜在机制,提出干预策略和未来研究方向。

关键词: 炎症, 衰弱, 机制

Abstract: The chronic inflammatory response is recognized as one of the central mechanisms accelerating aging and promoting frailty, establishing a vicious cycle of inflammation-frailty through multisystem interactions. Driven by non-infectious triggers such as cellular senescence and mitochondrial dysfunction, chronic inflammation suppresses anabolic growth factor expression while activating catabolic pathways, thereby accelerating sarcopenia development and promoting frailty progression. Conversely, frailty not only serves as a consequence of chronic inflammation but also may reciprocally exacerbate systemic inflammation through mechanisms including immune dysregulation, metabolic disturbances, mitochondrial dysfunction, and gut microbiota dysbiosis. This review synthesizes current evidence on the bidirectional relationship between frailty and inflammation, elucidates underlying pathophysiological mechanisms, and proposes targeted intervention strategies along with future research priorities in this emerging field.

Key words: inflammation, frailty, mechanism

中图分类号:

R592

段景宜, 马亚男, 阿尔有布, 冯舒琦, 袁慧, 廖锡楚, 高海英. 炎症与衰弱的关系研究进展[J]. 实用老年医学, 2025, 39(7): 649-653.

DUAN Jingyi, MA Yanan, Aeryoubu, FENG Shuqi, YUAN Hui, LIAO Xichu, GAO Haiying. Association of inflammation and frailty[J]. Practical Geriatrics, 2025, 39(7): 649-653.

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