实用老年医学

实用老年医学 ›› 2025, Vol. 39 ›› Issue (7): 669-673.doi: 10.3969/j.issn.1003-9198.2025.07.005

• 临床研究 • 上一篇    下一篇

早期限时喂养模式对代谢综合征病人代谢状况及衰老相关分泌表型的影响

陈梦琪, 范浩玲, 章媛媛, 吴婷玉, 张冬梅, 程凯   

  1. 210031 江苏省南京市,南京医科大学第四附属医院老年医学科(陈梦琪,范浩玲,章媛媛,吴婷玉);护理部(张冬梅,程凯)
  • 收稿日期:2024-08-01 出版日期:2025-07-20 发布日期:2025-07-22
  • 通讯作者: 程凯,Email:859181272@qq.com
  • 基金资助:
    江苏省老年健康科研项目(LKM2023027)

Effects of early time-restricted feeding on metabolic status and senescence-associated secretory phenotype in patients with metabolic syndrome

CHEN Mengqi, FAN Haoling, ZHANG Yuanyuan, WU Tingyu, ZHANG Dongmei, CHENG Kai   

  1. Department of Geriatrics (CHEN Mengqi, FAN Haoling, ZHANG Yuanyuan, WU Tingyu); Nurse Department (ZHANG Dongmei, CHENG Kai), the Fourth Affiliated Hospital of Nanjing Medical University, Nanjing 210031, China
  • Received:2024-08-01 Online:2025-07-20 Published:2025-07-22
  • Contact: CHENG Kai,Email:859181272@qq.com

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摘要： 目的 研究早期限时喂养(early time-restricted feeding, eTRF)模式对代谢综合征(metabolic syndrome, MS)病人代谢状况及衰老相关分泌表型(senescence-associated secretory phenotype, SASP)的影响。 方法 采用随机区组方法,将2022—2023年就诊于南京医科大学第四附属医院的60例MS病人随机分为对照组(30例)和干预组(30例)。对照组不限制进食时间及进食热量,干预组予以eTRF模式饮食。6周后比较各组病人干预前后的身体指数、血脂、血糖及SASP水平。 结果 在6周的干预期中有2例病人退出研究,进一步根据年龄将各组病人分为非老年亚组(＜60岁)和老年亚组(≥60岁),其中对照组老年亚组15例,非老年15例;eTRF组老年亚组14例,非老年亚组14例。干预6周后,4个亚组的体质量、BMI、腰围、TG、TC、LDL-C、HDL-C、FPG水平与干预前比较,差异均无统计学意义(P＞0.05),但组间各指标变化差值比较差异有统计学意义(P＜0.05),除外TC和HDL-C;eTRF组2个亚组的IL-6、IL-1β、TNF-α、IFN-γ水平均较干预前明显降低(P<0.05);但对照组2个亚组的IL-6、IL-1β、TNF-α、IFN-γ水平与干预前比较,差异均无统计学意义(P＞0.05)。 结论 eTRF模式能降低MS病人的SASP水平。

关键词: 早期限时喂养, 代谢综合征, 衰老相关分泌表型

Abstract: Objective To investigate the effects of early time-restricted feeding (eTRF) on metabolic status and senescence-associated secretory phenotype (SASP) in the patients with metabolic syndrome. Methods Using a randomized block grouping method, 60 patients with metabolic syndrome who were admitted to the Fourth Affiliated Hospital of Nanjing Medical University from 2022 to 2023 were randomly divided into the control group (30 cases) and the intervention group (30 cases).The control group did not limit their eating time and calorie intake, while the intervention group received an eTRF diet. The body indexes, blood lipids, blood glucose, and SASP levels were compared between the groups before and after 6 weeks of intervention. Results Two patients dropped out of the study during the 6-week intervention period.According to the age, each group was further divided into non-elderly subgroup (aged<60 years old) and elderly subgroup (aged≥60 years old). There were 15 cases in each subgroup of the control group, and 14 cases in each subgroup of the eTRF group.Compared to those before intervention, there were no statistically significant differences in the levels of body mass, body mass index,waist circumference, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose among the four subgroups after 6 weeks of intervention (P>0.05). However, the magnitudes of change (differences) between the subgroups for these indicators showed statistically differences, except for waist circumference, triglyceride and HDL-C. The levels of interleukin(IL)-6, IL-1β, tumor necrosis factor(TNF)-α and interferon(IFN)-γ in the two subgroups of the eTRF group were significantly reduced after 6 weeks of intervention (P<0.05), while those indicators did not changed significantly in the two subgroups of the control group after 6 weeks of intervention (P>0.05). Conclusions eTRF model can reduce the levels of SASP in the patients with metabolic syndrome.

Key words: early time-restricted feeding, metabolic syndrome, senescence-associated secretory phenotype

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