细胞衰老与2型糖尿病胰岛B细胞功能障碍的研究进展

doi:10.3969/j.issn.1003-9198.2024.05.021

摘要/Abstract

摘要： 细胞衰老指有复制能力的细胞在应激诱导后发生永久性细胞周期阻滞,是人体衰老的重要病理机制。T2DM是一种增龄性疾病,好发于老年人群。细胞衰老与T2DM的发生关系密切:一方面,细胞衰老导致胰岛素抵抗和胰岛B细胞功能障碍;另一方面,糖脂毒性及炎症微环境等又会促进胰岛B细胞衰老和功能障碍。靶向细胞衰老的治疗可降低糖尿病发生风险,在糖尿病及其并发症的防治中具有重要意义。

关键词: 细胞衰老, 2型糖尿病, 衰老相关分泌表型, 胰岛B细胞

中图分类号:

R 587.1

杨龙璇, 唐伟. 细胞衰老与2型糖尿病胰岛B细胞功能障碍的研究进展[J]. 实用老年医学, 2024, 38(5): 521-437.

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细胞衰老与2型糖尿病胰岛B细胞功能障碍的研究进展

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