老年T2DM病人肌少症发生与颈动脉粥样硬化的相关性研究

doi:10.3969/j.issn.1003-9198.2024.08.016

摘要/Abstract

摘要： 目的分析老年T2DM病人肌少症发生与颈动脉粥样硬化(AS)的相关性。方法回顾性收集本院2021年4月至2023年4月收治的97例老年T2DM病人临床资料,依据骨骼肌质量指数(ASMI)分为肌少症组41例、非肌少症组56例。收集病人临床资料及颈动脉超声指标,比较2组病人一般资料、颈动脉血流动力学参数、颈动脉AS分级情况,并分析影响老年T2DM病人肌少症发生的危险因素。结果肌少症组BMI、骨密度T值、胰岛素抵抗指数(HOMA-IR)、UA、ASMI水平均低于非肌少症组,差异有统计学意义(P＜0.05)。肌少症组颈动脉斑块数、Crouse积分、半定量积分、等级积分及颈动脉内中膜厚度(IMT)明显高于非肌少症组(P＜0.05)。肌少症组颈动脉AS分级以3级为主,非肌少症组以0级、1级为主(P＜0.05)。Logistic回归分析显示:BMI、颈动脉斑块数、颈动脉IMT、Crouse积分、半定量积分、等级积分为肌少症发生的危险因素(P<0.05)。结论老年T2DM病人肌少症发生与颈动脉AS有关,有合并动脉AS斑块者需警惕肌少症发生,需积极采取相应预防手段,以改善病情进展。

关键词: 老年人, 2型糖尿病, 肌少症, 颈动脉粥样硬化, 相关性, 骨骼肌质量指数

Abstract: Objective To analyze the correlation between sarcopenia and carotid atherosclerosis in the elderly patients with type 2 diabetes mellitus(T2DM). Methods The clinical data of 97 elderly patients with T2DM admitted to our hospital from April 2021 to April 2023 were collected retrospectively. According to the skeletal muscle mass index (ASMI), the patients were divided into the sarcopenia group (41 cases) and the non-sarcopenia group (56 cases).The clinical data and carotid ultrasound indicators were collected and compared between the two groups. The risk factors affecting the occurrence of sarcopenia in the elderly patients with T2DM were analyzed. Results The levels of body mass index (BMI), T value of bone density, homextasis model assessment-insulin resitance (HOMA-IR), uric acid and ASMI in the sarcopenia group were significantly lower than those in the non-sarcopenia group (P<0.05).The number of carotid plaques, the Crouse score, semi-quantitative score, and grade score, carotid intima-media thickness (cIMT) were higher in the sarcopenia group than those in the non-sarcopenia group (P<0.05).The main grade of carotid atherosclerosis was grade 3 in the sarcopenia group, compared with grade 0 or 1 in the non-sarcopenia group, and the proportion of the two groups was significantly different (P<0.01).Logistic regression analysis showed that BMI, number of carotid plaque, cIMT, Crouse score, semi-quantitative score and grade score were risk factors for sarcopenia in the elderly patients with T2DM (P<0.05). Conclusions There is a certain correlation between sarcopenia and carotid atherosclerosis in the elderly patients with T2DM. Preventive measures should be actively taken to improve the progress of disease.

Key words: aged, type 2 diabetes, sarcopenia, carotid atherosclerosis, correlation, skeletal muscle mass index

中图分类号:

R587.1

梁杉杉, 梁欢, 杨珊, 刘建凤. 老年T2DM病人肌少症发生与颈动脉粥样硬化的相关性研究[J]. 实用老年医学, 2024, 38(8): 826-830.

LIANG Shanshan, LIANG Huan, YANG Shan, LIU Jianfeng. Relationship between sarcopenia and carotid atherosclerosis in elderly patients with type 2 diabetes mellitus[J]. Practical Geriatrics, 2024, 38(8): 826-830.

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