肺衰老与慢性呼吸系统疾病研究现状及进展

doi:10.3969/j.issn.1003-9198.2024.08.002

摘要/Abstract

摘要： 随着人口老龄化,肺衰老及其导致的疾病如COPD、特发性肺纤维化、哮喘和肺癌受到关注。衰老机制涉及端粒缩短、氧化应激、线粒体功能障碍等,衰老细胞的累积和功能下降与多种呼吸疾病相关。目前,抗衰老治疗包括SIRT1激动剂、烟酰胺膘嘌呤二核苷酸补充剂、mTOR抑制剂和Senolytics药物等,但仍处于早期临床阶段,深入理解肺衰老机制对于开发有效治疗策略至关重要。本文综述了肺衰老与慢性呼吸系统疾病之间的关联及其研究进展。

中图分类号:

李湘, 栗萱, 田应选. 肺衰老与慢性呼吸系统疾病研究现状及进展[J]. 实用老年医学, 2024, 38(8): 761-765.

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