老年T2DM病人肌少症与肺功能的相关性研究

doi:10.3969/j.issn.1003-9198.2025.07.009

摘要/Abstract

摘要： 目的分析老年T2DM病人肌少症与肺功能指标的相关性。方法选取2023年1月至2024年9月淮安市第一人民医院老年科门诊及住院治疗的老年T2DM病人250例为研究对象,根据是否合并肌少症分为肌少症组(n=75)和非肌少症组(n=175例)。比较2组一般资料、肌肉质量相关指标和肺功能等指标的差异。采用相关分析评估与老年T2DM合并肌少症病人肺功能指标相关的因素。结果肌少症组的步速、握力、BMI、Hb、淋巴细胞计数和FEV1、FEV1/FVC均明显低于非肌少症组;糖尿病病程、FPG、HbA1c和ALT水平明显高于非肌少症组,差异均有统计学意义(P＜0.05)。老年T2DM合并肌少症病人FEV1、FEV1/FVC与年龄、糖尿病病程呈显著负相关(P<0.05);与BMI、握力、步速、肌肉质量呈显著正相关(0.5< r <0.8,P<0.05)。老年T2DM非肌少症病人FEV1、FEV1/FVC与握力、步速、肌肉质量呈弱相关(0.3< r <0.5,P<0.05)。多元线性回归分析显示,糖尿病病程、年龄和肌少症为T2DM病人FEV1和FEV1/FVC下降的独立影响因素。结论老年T2DM合并肌少症病人肺功能下降风险较非肌少症病人高,尽早筛查并有效干预肌少症对于老年T2DM 病人肺功能障碍并发症的防治有重要意义。

关键词: 2型糖尿病, 肌少症, 肺功能, 相关性

Abstract: Objective To investigate the correlation between sarcopenia and lung function in the elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 250 elderly T2DM patients treated in the Geriatric Department of Huai’an First People’s Hospital from January 2023 to September 2024 were enrolled in this study. Based on the presence of sarcopenia, the subjects were divided into sarcopenia group(75 cases) and non-sarcopenia group (175 cases). The differences in general data, related indexes of muscle measurements and lung function were compared between the two groups. Correlation analysis was performed to investigate the factors associated with lung function in the elderly T2DM patients. Results The levels of walking speed and grip strength, body mass index (BMI), hemoglobin, lymphocyte count, forced expiratory volume in 1 second (FEV1), and FEV1/ forced vital capacity (FVC) in sarcopenia group were significantly lower than those in non-sarcopenia group (P<0.05). The duration of T2DM, and the levels of fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and alanine aminotransferase (ALT) were significantly higher than those in non-sarcopenia group (P<0.05). In sarcopenia group, FEV1 and FEV1/FVC showed significant negative correlations with age and T2DM duration (P<0.05), while showing positive correlations with BMI, grip strength, gait speed, and muscle mass (0.5<r<0.8, P<0.05). In non-sarcopenia group, FEV1 and FEV1/FVC were weakly correlated with grip strength, gait speed, and muscle mass (0.3<r<0.5, P<0.05). Multivariate linear regression analysis showed that age, duration of T2DM, and sarcopenia were independent factors associated with FEV1 and FEV1/FVC in the elderly T2DM patients. Conclusions The risk of lung function decline in the elderly T2DM patients with sarcopenia is higher than that in non-sarcopenia patients. Early screening and effective intervention for sarcopenia are crucial for preventing and managing pulmonary dysfunction complications in the elderly T2DM patients.

Key words: type 2 diabetes mellitus, sarcopenia, lung function, correlation

中图分类号:

R685

张少红, 张灵, 王梦茜, 孙梦悦, 陆鹏, 赵松青, 汪为民. 老年T2DM病人肌少症与肺功能的相关性研究[J]. 实用老年医学, 2025, 39(7): 693-697.

ZHANG Shaohong, ZHANG Ling, WANG Mengxi, SUN Mengyue, LU Peng,ZHAO Songqing, WANG Weimin. Relationship of sarcopenia with lung function in elderly patients with type 2 diabetes mellitus[J]. Practical Geriatrics, 2025, 39(7): 693-697.

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