环境暴露与肌少症的关系研究进展

doi:10.3969/j.issn.1003-9198.2025.01.003

摘要/Abstract

摘要： 随着社会飞速发展,环境污染的危害日益凸显。人口老龄化加剧的背景下,肌少症病人的数量不断增加,加剧了国家公共卫生负担。本文综述了常见环境暴露如空气污染、重金属暴露、噪音污染等对肌少症的影响及机制,阐明环境污染导致机体的线粒体功能障碍和慢性炎症等一系列分子生物学机制与肌少症的发生进展有着密不可分的联系,强调重金属暴露的危害,旨在为肌少症的临床诊治和科学研究提供新思路。

关键词: 环境暴露, 肌少症, 重金属暴露, 空气污染

Abstract: With the rapid development of society, the harm of environmental pollution has become increasingly prominent. With the progress of population aging, the prevelence of sarcopenia is increasing, which increases the national public health burden. This article reviews the effects and mechanisms of common environmental exposures such as air pollution, heavy metal exposure and noise pollution on sarcopenia, and elucidates that mitochondrial dysfunction and chronic inflammation caused by environmental pollution are closely related to the occurrence and progression of sarcopenia, and emphasizes the hazards of heavy metal exposure, in order to provide new ideas for the clinical diagnosis, treatment, and scientific research of sarcopenia.

Key words: environmental exposure, sarcopenia, heavy metal exposure, air pollution

中图分类号:

R 685

董小菲, 张飞, 王佳贺. 环境暴露与肌少症的关系研究进展[J]. 实用老年医学, 2025, 39(1): 8-11.

DONG Xiaofei, ZHANG Fei, WANG Jiahe. Relationship between environmental exposure and sarcopenia[J]. Practical Geriatrics, 2025, 39(1): 8-11.

参考文献

[1] CRUZ-JENTOFT A J, BAHAT G, BAUER J, et al. Sarcopenia: revised European consensus on definition and diagnosis[J]. Age Ageing, 2019, 48(1): 16-31.
[2] CRUZ-JENTOFT A J, SAYER A A. Sarcopenia[J]. Lancet, 2019, 393(10191): 2636-2646.
[3] ROSENBERG I H. Sarcopenia: origins and clinical relevance[J]. Clin Geriatr Med, 2011, 27(3): 337-339.
[4] 彭希哲, 周祥. 中国人口发展与老龄化应对[J]. 新金融, 2024(4): 8-13.
[5] YUAN S, LARSSON S C. Epidemiology of sarcopenia: prevalence, risk factors, and consequences[J]. Metabolism, 2023, 144: 155533.
[6] LAI Z, YANG Y, QIAN Z M, et al. Is ambient air pollution associated with sarcopenia? Results from a nation-wide cross-sectional study[J]. Age Ageing, 2022, 51(11): afac249.
[7] 吕新萍. 家庭社会功能的重建与家庭综合服务的推进——从《家庭教育促进法》的制定与实施谈起[J]. 少年儿童研究, 2022(2): 37-39.
[8] SOUSA A S, GUERRA R S, FONSECA I, et al. Financial impact of sarcopenia on hospitalization costs[J]. Eur J Clin Nutr, 2016, 70(9): 1046-1051.
[9] ZHANG F, LI T, CHEN B, et al. Air pollution weaken your muscle? Evidence from a cross-sectional study on sarcopenia in central China[J]. Ecotoxicol Environ Saf, 2023, 258: 114962.
[10] FORSBERG B, STJERNBERG N, WALL S. People can detect poor air quality well below guideline concentrations: a prevalence study of annoyance reactions and air pollution from traffic[J]. Occup Environ Med, 1997, 54(1): 44-48.
[11] CHEN S W, LIN C Y, CHEN C Y, et al. Long-term exposure to air pollution and risk of sarcopenia in adult residents of Taiwan: a nationwide retrospective cohort study[J]. BMC Public Health, 2023, 23(1): 2172.
[12] LI Y, OU X, OU Q, et al. Air pollution and risk of sarcopenia: a two-sample Mendelian randomized study[J]. Chemosphere, 2024, 351: 141145.
[13] PICCA A, CALVANI R. Molecular mechanism and pathogenesis of sarcopenia: an overview[J]. Int J Mol Sci, 2021, 22(6): 3032.
[14] VON ZGLINICKI T, PILGER R, SITTE N. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts[J]. Free Radic Biol Med, 2000, 28(1): 64-74.
[15] PANASEVICH S, LEANDER K, ROSENLUND M, et al. Associations of long- and short-term air pollution exposure with markers of inflammation and coagulation in a population sample[J]. Occup Environ Med, 2009, 66(11): 747-753.
[16] HU Z, TIAN Y, SONG X, et al. Associations between indoor air pollution for cooking and heating with muscle and sarcopenia in Chinese older population[J]. J Cachexia Sarcopenia Muscle, 2023, 14(5): 2029-2043.
[17] CHAN S M H, CERNI C, PASSEY S, et al. Cigarette smoking exacerbates skeletal muscle injury without compromising its regenerative capacity[J]. Am J Respir Cell Mol Biol, 2020, 62(2): 217-230.
[18] ZHAO L, FANG J, TANG S, et al. PM_2.5and serum metabolome and insulin resistance, potential mediation by the gut microbiome: apopulation-based panel study of older adults in China[J]. Environ Health Perspect, 2022, 130(2): 27007.
[19] ROM O, KAISARI S, AIZENBUD D, et al. Cigarette smoke and muscle catabolism in C2 myotubes[J]. Mech Ageing Dev, 2013, 134(1/2): 24-34.
[20] XU T, XIA R, HE F, et al. 5-Hydroxymethylfurfural induces mice frailty through cell senescence-associated sarcopenia caused by chronic inflammation[J]. Heliyon, 2023, 9(2): e13217.
[21] HUANG Q, WAN J, NAN W, et al. Association between manganese exposure in heavy metals mixtures and the prevalence of sarcopenia in US adults from NHANES 2011-2018[J]. J Hazard Mater, 2024, 464: 133005.
[22] YOO J I, HA Y C, LEE Y K, et al. High levels of heavy metals increase the prevalence of sarcopenia in the elderly population[J]. J Bone Metab, 2016, 23(2): 101-109.
[23] KUMAWAT R, TOMAR R S. Heavy metal exposure induces Yap1 and Hac1 mediated derepression of GSH1 and KAR2 by Tup1-Cyc8 complex[J]. J Hazard Mater, 2022, 429: 128367.
[24] KIM Y, MEN S S, LIANG C, et al. Effects of long-term exposures to low iron and branched-chain amino acid containing diets on aging skeletal muscle of Fisher 344 × Brown Norway rats[J]. Appl Physiol Nutr Metab, 2018, 43(2): 165-173.
[25] JIANG X, XING X, ZHANG Y, et al. Lead exposure activates the Nrf2/Keap1 pathway, aggravates oxidative stress, and induces reproductive damage in female mice[J]. Ecotoxicol Environ Saf, 2021, 207: 111231.
[26] MÜNZEL T, SØRENSEN M, SCHMIDT F, et al. The adverse effects of environmental noise exposure on oxidative stress and cardiovascular risk[J]. Antioxid Redox Signal, 2018, 28(9): 873-908.
[27] DAMLUJI A A, ALFARAIDHY M, ALHAJRI N, et al. Sarcopenia and cardiovascular diseases[J]. Circulation, 2023, 147(20): 1534-1553.
[28] GIELEN E, DUPONT J, DEJAEGER M, et al. Sarcopenia, osteoporosis and frailty[J]. Metabolism, 2023, 145: 155638.
[29] ZHANG A, ZOU T, GUO D, et al. The immune system can hear noise[J]. Front Immunol, 2021, 11: 619189.
[30] PEREZ E B, MARTAGÓN V L, VAZQUEZ-MEDINA J P, et al. Exposure to bis (2-ethylhexyl) phthalate (DEHP) induces oxidative stress in human skeletal muscle cells[J]. Free Radic Biol Med, 2022, 180: s72.
[31] HAN J W, SHIN S K, BAE H R, et al. Wheat seedlings extract ameliorates sarcopenia in aged mice by regulating protein synthesis and degradation with anti-inflammatory and mitochondrial biogenesis effects[J]. Phytomedicine, 2024, 130: 155747.
[32] HUANG S J, LAI M J, CHEN A Y, et al. De novo biosynthesis of 3-hydroxy-3-methylbutyrate as anti-catabolic supplement by metabolically engineered Escherichia coli[J]. Metab Eng, 2024, 84: 48-58.