老年人体力活动水平与肌少症发生风险关系的剂量-反应Meta分析

doi:10.3969/j.issn.1003-9198.2024.09.011

摘要/Abstract

摘要： 目的分析体力活动与肌少症发病风险之间的关系及二者间的剂量-反应关系,为老年人肌少症的预防提供参考依据。方法检索PubMed、Web of Science、Embase、中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库,收集2023年5月前有关老年人体力活动与肌少症发病关系的中英文队列研究。由2名研究者分别独立筛选文献、提取资料,并进行文献偏倚风险评价。运用Stata 17.0和RevMan 5.4软件进行Meta分析,计算体力活动与肌少症发病风险的合并OR值及其95%CI,并采用限制性立方样条函数和广义最小二乘估计方法分析体力活动量与肌少症发病风险的剂量-反应关系。结果共纳入6篇文献,共8784名参与者,包括1275例肌少症病人。Meta分析结果表明,体力活动与肌少症发生风险呈负相关(OR=0.59,95%CI:0.52～0.67),研究间异质性较低,不存在发表偏倚。剂量-反应分析结果显示,体力活动量与肌少症发生风险之间呈U型非线性关系,体力活动水平为10.85 mMET-h/wk时,对肌少症的预防作用最为显著(OR＝0.40,95%CI:0.32～0.50)。结论老年人通过增加体力活动量可以获得实质性的、较显著的肌少症预防益处,即使是进行低于WHO推荐的8.8 mMET-h/wk体力活动也能获得较大的肌少症预防作用,体力活动水平达10.85 mMET-h/wk时保护作用最明显。

关键词: 肌少症, 体力活动, 队列研究, Meta分析

Abstract: Objective To explore the dose-response association between physical activity and sarcopenia based on a Meta-analysis. Methods PubMed, Web of Science, Embase, VIP, Wanfang Database, SinoMed and CNKI databases were searched to collect cohort studies about physical activity and the risk of sarcopenia from the establishment of the database to May 2023. Two researchers independently completed literature screening and data extraction and quality assessment. Meta-analysis was conducted with Stata 17.0 and RevMan 5.4 software to calculate pooled odds ratio (OR) and corresponding 95% confidence interval (CI), and the dose-response relationship between physical activity and risk of sarcopenia was analyzed by using restricted cubic spline function and generalized least squares estimation. Results A total of 6 studies involving 8784 participants and 1275 sarcopenic patients were included.The results of Meta-analysis revealed that physical activity was negatively correlated with sarcopenia (OR=0.59, 95%CI :0.52-0.67). Low heterogeneity was shown, and no publication bias was found. Nonlinear dose-response analysis showed a U-shaped association between physical activity and sarcopenia. When the level of physical activity reached 10.85 mMET-h/wk, the preventive effect on sarcopenia was the most significant (OR＝0.40, 95%CI:0.32-0.50). Conclusions Elderly people can achieve substantial and significant benefits in preventing sarcopenia by increasing their physical activity levels, even when the level is lower than 8.8 mMET-h/wk recommended by the World Health Organization. The protective effect of sarcopenia is most obvious when the level of physical activity reaches 10.85 mMET-h/wk.

Key words: sarcopenia, physical activity, cohort study, Meta-analysis

中图分类号:

R685

戚嘉萤, 殷曈曈, 王芳芳, 张慧, 王丽. 老年人体力活动水平与肌少症发生风险关系的剂量-反应Meta分析[J]. 实用老年医学, 2024, 38(9): 905-910.

QI Jiaying, YIN Tongtong, WANG Fangfang, ZHANG Hui, WANG Li. A dose-response Meta-analysis of the association between physical activity and the risk of sarcopenia in the elderly[J]. Practical Geriatrics, 2024, 38(9): 905-910.

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