线粒体功能障碍相关分子机制在肌少症发病过程中的作用研究进展

doi:10.3969/j.issn.1003-9198.2024.01.017

摘要/Abstract

摘要： 肌少症是老年人群的常见疾病,也是目前老年病的热门研究之一。目前对肌少症的研究已从临床表现及诊断方法发展到对分子水平发病机制的研究。线粒体功能障碍被认为是导致肌肉老化的主要因素之一。线粒体功能障碍包括氧化应激功能紊乱、线粒体融合裂变失调、线粒体自噬障碍和线粒体凋亡信号异常。此外,肌外因素如炎症、内分泌老龄化改变、血管老化等,也通过影响线粒体功能参与肌少症发病。本文综述了肌少症病人肌肉线粒体功能障碍的发病机制,以及肌外因素通过影响线粒体影响肌少症的发病机制,探讨线粒体功能障碍与肌少症之间的相关机制。

关键词: 肌少症, 线粒体自噬, 线粒体动力学, 活性氧

中图分类号:

R 592

周艳雯, 李秀芬, 张长明. 线粒体功能障碍相关分子机制在肌少症发病过程中的作用研究进展[J]. 实用老年医学, 2024, 38(1): 72-76.

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