自噬在心血管健康和疾病中的研究进展

doi:10.3969/j.issn.1003-9198.2024.01.018

摘要/Abstract

摘要： 自噬是细胞分解并破坏其细胞质中衰老、受损或异常蛋白质和其他物质的过程,对体内稳态和生存至关重要。心血管疾病是世界范围内发病和死亡的主要原因,严重危害人类健康,其发病机制复杂,目前研究主要集中在炎性反应、免疫机制、细胞凋亡等方面。近年来,自噬在糖尿病心肌病、动脉粥样硬化、冠心病、心肌肥厚和心力衰竭等心血管疾病中的作用得到部分验证,本文综述了此方面的研究进展,重点介绍自噬的心血管保护作用及潜在的诊疗价值。

中图分类号:

R 54

张书虎, 李甜甜. 自噬在心血管健康和疾病中的研究进展[J]. 实用老年医学, 2024, 38(1): 77-80.

参考文献

[1] FLEMINGA, BOURDENX M, FUJIMAKI M, et al. The different autophagydegradation pathways and neurodegeneration[J]. Neuron, 2022, 110(6): 935-966.
[2] CAO W, LI J, YANG K, et al. An overview of autophagy: mechanism, regulation and research progress[J]. Bull Cancer, 2021, 108(3): 304-322.
[3] GE Y, ZHOU M, CHEN C, et al. Role of AMPK mediated pathways in autophagy and aging[J]. Biochimie, 2022, 195:100-113.
[4] CAI C, GUO Z, CHANG X, et al. Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway[J]. Redox Biol, 2022, 52:102288.
[5] AVAGIMYAN A, POPOV S, SHALNOVA S. The pathophysiological basis of diabetic cardiomyopathy development[J]. Curr Probl Cardiol, 2022, 47(9): 101156.
[6] INGELFINGER J R, JARCHO J A. Increase in the incidence of diabetes and its implications[J]. N Engl J Med, 2017, 376(15): 1473-1474.
[7] KETENCI M, ZABLOCKI D, SADOSHIMA J. Mitochondrial quality control mechanisms during diabetic cardiomyopathy[J]. JMA J, 2022, 5(4): 407-415.
[8] TONG M, SAITOT, ZHAI P, et al. Mitophagy is essential for maintaining cardiac function during high fat diet-induced diabetic cardiomyopathy[J]. Circ Res, 2019, 124(9): 1360-1371.
[9] WANG H, WANG L, HU F, et al. Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway[J]. Cardiovasc Diabetol, 2022, 21(1): 205.
[10] KIRCHNER P, BOURDENX M, MADRIGAL-MATUTE J, et al. Correction: proteome-wide analysis of chaperone-mediated autophagy targeting motifs[J]. PLoS Biol, 2022, 20(2): e3001550.
[11] HIEDA T, SHINGU Y, SUGIMOTO S, et al. Effects of trehalose on recurrence of remodeling after ventricular reconstruction in rats with ischemic cardiomyopathy[J]. Heart Vessels, 2022, 37(3): 528-537.
[12] SIDDHI J, SHERKHANE B, KALAVALA A K, et al. Melatonin prevents diabetes-induced nephropathy by modulating the AMPK/SIRT1 axis: focus on autophagy and mitochondrial dysfunction[J]. Cell Biol Int, 2022, 46(12): 2142-2157.
[13] GUO Q, XU L, LI H, et al. Retraction note: progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress[J]. Lipids Health Dis, 2022, 21(1): 136.
[14] ZANG H, WU W, QI L, et al. Autophagy inhibition enables Nrf2 to exaggerate the progression of diabetic cardiomyopathy in mice[J]. Diabetes, 2020, 69(12): 2720-2734.
[15] DEWANJEE S, VALLAMKONDU J, KALRAR S, et al. Autophagy in the diabetic heart: a potential pharmacotherapeutic target in diabetic cardiomyopathy[J]. Ageing Res Rev, 2021, 68:101338.
[16] KEETER W C, MA S, STAHR N, et al. Atherosclerosis and multi-organ-associated pathologies[J]. Semin Immunopathol, 2022, 44(3): 363-374.
[17] ROBICHAUD S, RASHEED A, PIETRANGELO A, et al. Autophagy is differentially regulated in leukocyte and nonleukocyte foam cells during atherosclerosis[J]. Circ Res, 2022, 130(6): 831-847.
[18] YANG N, DONG B, SONG Y, et al. Apolipoprotein J attenuates vascular restenosis by promoting autophagy and inhibiting the proliferation and migration of vascular smooth muscle cells[J]. J Cardiovasc Transl Res, 2022, 15(5): 1086-1099.
[19] HUA Y, ZHANG J, LIU Q, et al. The induction of endothelial autophagy and its role in the development of atherosclerosis[J]. Front Cardiovasc Med, 2022, 9:831847.
[20] MAMELI E, MARTELLO A, CAPORALI A. Autophagy at the interface ofendothelial cell homeostasis and vascular disease[J]. FEBS J, 2022, 289(11): 2976-2991.
[21] ZHANG H, GE S, NI B, et al. Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages[J]. Autophagy, 2021, 17(12): 4218-4230.
[22] QIAO L, MA J, ZHANG Z, et al. Deficient chaperone-mediated autophagy promotes inflammation and atherosclerosis[J]. Circ Res, 2021, 129(12): 1141-1157.
[23] MA S, CHEN J, FENG J, et al. Melatonin ameliorates the progression of atherosclerosis via mitophagy activation and NLRP3 inflammasome inhibition[J]. Oxid Med Cell Longev, 2018, 2018:9286458.
[24] EVANS T D, JEONG S J, ZHANG X, et al. TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis[J]. Autophagy, 2018, 14(4): 724-726.
[25] HE L, ZHOU Q, HUANG Z, et al. PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions[J]. J Cell Physiol, 2019, 234(6): 8668-8682.
[26] GAO C, WANG R, LI B, et al. TXNIP/Redd1 signalling and excessive autophagy: a novel mechanism of myocardial ischaemia/reperfusion injury in mice[J]. Cardiovasc Res, 2020, 116(3): 645-657.
[27] MU J, ZHANG D, TIAN Y, et al. BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1/Parkin-mediated mitophagy in vivo[J]. J Mol Cell Cardiol, 2020, 149:1-14.
[28] HE W, TONG G, FAN H, et al. Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB[J]. Exp Cell Res, 2023, 423(2): 113469.
[29] HE L, CHU Y, YANG J, et al. Activation of autophagic flux maintains mitochondrial homeostasis during cardiac ischemia/reperfusion injury[J]. Cells, 2022, 11(13): 2111.
[30] WEI P, YANG X J, FU Q, et al. Intermedin attenuates myocardial infarction through activation of autophagy in a rat model of ischemic heart failure via both cAMP and MAPK/ERK1/2 pathways[J]. Int J Clin Exp Pathol, 2015, 8(9): 9836-9844.