实用老年医学

实用老年医学 ›› 2024, Vol. 38 ›› Issue (9): 901-904.doi: 10.3969/j.issn.1003-9198.2024.09.010

• 临床研究 • 上一篇    下一篇

老年混合型早期胃癌淋巴结转移的危险因素分析

王振宇, 袁颖, 项英, 刘金燕, 吴海, 王萌, 徐桂芳   

  1. 210008 江苏省南京市,南京大学医学院附属鼓楼医院消化内科(王振宇,袁颖,项英,吴海,王萌,徐桂芳);
    211299 江苏省南京市,东南大学附属中大医院溧水分院,溧水区人民医院消化内科(刘金燕)
  • 收稿日期:2024-02-09 出版日期:2024-09-20 发布日期:2024-10-23
  • 通讯作者: 徐桂芳,Email:13852293376@163com
  • 基金资助:
    江苏省社发基金资助项目(BE2021601)

Risk factors of lymph node metastasis in elderly patients with mixed-type early gastric cancer

WANG Zhenyu, YUAN Ying, XIANG Ying, LIU Jinyan, WU Hai, WANG Meng, XU Guifang   

  1. Department of Gastroenterology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China(WANG Zhenyu, YUAN Ying, XIANG Ying, WU Hai, WANG Meng, XU Guifang);
    Department of Gastroenterology, Nanjing Lishui People’s Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing 211299, China(LIU Jinyan)
  • Received:2024-02-09 Online:2024-09-20 Published:2024-10-23
  • Contact: XU Guifang, Email:13852293376@163com

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摘要： 目的 探讨老年混合型早期胃癌淋巴结转移的相关危险因素。方法 回顾性分析2010年1月至2023年3月在南京大学医学院附属鼓楼医院行根治性胃癌切除+淋巴结清扫术且术后病理符合混合型早期胃癌的老年病人(≥60岁)的临床病理资料。采用单因素分析和Logistic回归分析老年混合型早期胃癌淋巴结转移的危险因素。结果 共纳入212例老年混合型早期胃癌病人,淋巴结转移阳性44例(20.8%)。单因素分析结果提示,肿瘤位置(P=0.035)、病变大小(P=0.006)、浸润深度(P＜0.001)及脉管侵犯(P＜0.001)与淋巴结转移有关;多因素Logistic回归分析提示,肿瘤位于胃下1/3(OR=4.109,95%CI:1.128～14.961,P=0.032)、黏膜下层浸润(OR=3.640,95%CI:1.163～11.391,P=0.026)和脉管侵犯(OR=3.684,95%CI:1.602～8.470,P=0.002)是淋巴结转移的独立危险因素。结论 肿瘤部位、浸润深度、脉管侵犯是老年混合型早期胃癌病人淋巴结转移的独立危险因素。

关键词: 早期胃癌, 混合型, 淋巴结转移, 危险因素

Abstract: Objective To investigate the risk factors of lymph node metastasis(LNM) in the elderly patients with mixed-type early gastric cancer(EGC). Methods The clinicopathological features of the elderly patients with mixed-type EGC undergoing radical gastrectomy and lymph node dissection from January 2010 to March 2023 at Nanjing Drum Tower Hospital were retrospectively analyzed. The risk factors of LNM in the elderly patients with mixed-type EGC were analyzed by univariate analysis and Logistic regression analysis. Results A total of 212 elderly patients with mixed-type EGC were enrolled,and 44 (20.8%) cases presented with lymph node metastasis.Univariate analysis indicated that tumor location (P=0.035), tumor size (P=0.006), invasion depth (P<0.001) and vascular invasion (P<0.001) were related with LNM. Multivariate regression analysis showed that tumor located at lower third of stomach(OR=4.109,95%CI:1.128-14.961,P=0.032), submucosal infiltration (OR=3.640,95%CI:1.163-11.391,P=0.026) and vascular invasion(OR=3.684,95%CI:1.602-8.470,P=0.002)were the independent risk factors for LNM. Conclusions Tumor location, depth of invasion and vascular invasion are the independent risk factors of LNM in the elderly patients with mixed-type EGC.

Key words: early gastric cancer, mixed-type, lymph node metastasis, risk factors

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